Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | PHLPP2 | Q6ZVD8 | 1/20 | 0.40 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.38 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.38 |
| ▸ | SSTR2 | P30874 | 3/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 2/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7795748 | 0.97 | CHRNB4 (0.41) | CYP1A2CYP2D6CYP2C19SMN1; SMN2HIF1A | |
| SCHEMBL7795875 | 0.95 | CYP1A2 (0.40) | CYP1A2CYP2D6CYP2C19SMN1; SMN2HIF1A | |
| SCHEMBL7795695 | 0.94 | CYP1A2 (0.42) | CYP1A2CYP2D6CYP2C19SMN1; SMN2HIF1A | |
| SCHEMBL7786122 | 0.94 | KCNA3 (0.39) | SSTR2PIM1PIM2KCNA3HTR2B | |
| SCHEMBL7795843 | 0.94 | KCNA3 (0.39) | SSTR2PIM1PIM2KCNA3HTR2B | |
| SCHEMBL7786284 | 0.93 | CHRNB4 (0.39) | CYP1A2CYP2D6CYP2C19SMN1; SMN2HIF1A | |
| SCHEMBL7795945 | 0.92 | CHRNB4 (0.40) | CYP1A2CYP2D6CYP2C19SMN1; SMN2HIF1A | |
| SCHEMBL7794866 | 0.92 | SSTR2 (0.37) | SSTR2PIM1PIM2KCNA3HTR2B | |
| SCHEMBL7792135 | 0.91 | TTR (0.37) | SSTR2PIM1PIM2KCNA3HTR2B | |
| SCHEMBL7792331 | 0.91 | KCNA3 (0.40) | CHRNB4CHRNA3KCNA3HTR2BHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0906268-B1 | ALKYLOXYAMINO SUBSTITUTED FLUORENONES AND THEIR USE AS PROTEIN KINASE C INHIBITORS | AVENTIS PHARMA INC (US) | 2001-11-28 | — | — | EP | disclosed |
| US-6004959-A | HYPOTENSIVE, ANTITUMOR, ANTIINFLAMMATORY AND ANTIASTHMATIC AGENTS; ANGIOGENESIS AND ALVEOLAR MACROPHAGE ACTIVATION INHIBITORS | HOECHST MARION ROUSSEL, INC. (US) | 1999-12-21 | — | — | US | disclosed |