Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 18/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 7/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 5/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.34 |
| ▸ | HDAC7 | Q8WUI4 | 5/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.34 |
| ▸ | HDAC10 | Q969S8 | 5/20 | 0.34 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.34 |
| ▸ | HDAC9 | Q9UKV0 | 5/20 | 0.34 |
| ▸ | HDAC5 | Q9UQL6 | 5/20 | 0.34 |
| ▸ | KDM1A | O60341 | 3/20 | 0.33 |
| ▸ | RYR2 | Q92736 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7797154 | 0.82 | HDAC6 (0.42) | HDAC6HDAC8HDAC1KDM1AALDH1A1 | |
| SCHEMBL1174569 | 0.80 | HDAC6 (0.50) | HDAC6HDAC1ALDH1A1 | |
| SCHEMBL1174479 | 0.79 | HDAC1 (0.48) | HDAC6HDAC8HDAC3HDAC4HDAC1 | |
| SCHEMBL1174439 | 0.79 | HPGD (0.47) | HDAC6HDAC8HDAC3HDAC1HDAC2 | |
| SCHEMBL7796732 | 0.78 | NAMPT (0.40) | HDAC6ALDH1A1HPGDMAPK1 | |
| SCHEMBL7797186 | 0.78 | HDAC6 (0.54) | HDAC6HDAC8HDAC3HDAC4HDAC1 | |
| SCHEMBL7799029 | 0.78 | NPC1 (0.52) | HDAC6HDAC8HDAC3HDAC4HDAC1 | |
| SCHEMBL1173764 | 0.78 | HDAC6 (0.67) | HDAC6HDAC8HDAC3HDAC1HDAC7 | |
| SCHEMBL7797158 | 0.78 | HRH4 (0.56) | HDAC6HDAC8HDAC3HDAC4HDAC1 | |
| SCHEMBL12869062 | 0.78 | HDAC6 (0.39) | HDAC6ALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010151317-A1 | SUBSTITUTED HYDROXAMIC ACIDS AND USES THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2010-12-29 | — | — | WO | disclosed |