⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7831061 | 0.74 | — | — | |
| SCHEMBL5611694 | 0.73 | MAPT (0.34) | — | |
| SCHEMBL1866638 | 0.72 | — | — | |
| SCHEMBL7616396 | 0.71 | — | — | |
| SCHEMBL1721038 | 0.65 | — | — | |
| SCHEMBL8922730 | 0.64 | — | — | |
| SCHEMBL611093 | 0.64 | — | — | |
| SCHEMBL2016299 | 0.62 | — | — | |
| SCHEMBL12494175 | 0.61 | MAPT (0.36) | — | |
| SCHEMBL12493384 | 0.58 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0591583-B1 | Benzo (f) quinolinones as 5-alpha-reductase inhibitors | LILLY CO ELI (US) | 2001-12-19 | — | — | EP | disclosed |
| EP-0532190-B1 | Benzo(f)quinolinones as 5-alpha-reductase inhibitors | LILLY CO ELI (US) | 2000-12-27 | — | — | EP | disclosed |
| EP-0591582-B1 | Hexahydrobenzo (f) quinolinones as 5-alpha-reductase inhibitors | LILLY CO ELI (US) | 1999-01-20 | — | — | EP | disclosed |
| EP-0531026-B1 | Hexahydrobenzo[f]quinolinones as 5-alpha-reductase inhibitors | LILLY CO ELI (US) | 1998-11-18 | — | — | EP | disclosed |
| US-5622962-A | PROSTATE CANCER, SKIN DISORDERS, BALDNESS | ELI LILLY AND COMPANY (US) | 1997-04-22 | — | — | US | disclosed |
| WO-1996035422-A1 | METHODS FOR INHIBITING BONE LOSS | ELI LILLY AND COMPANY (US) | 1996-11-14 | — | — | WO | disclosed |
| US-5541190-A | TREATING BENIGN PROSTATIC HYPERPLASIA, MALE PATTERN BALDNESS, PROSTATIC CANCER, ANDROGENIC ALOPECIA | ELI LILLY AND COMPANY (US) | 1996-07-30 | — | — | US | disclosed |
| US-5495021-A | STEROID 5 ALPHA-REDUCTASE INHIBITORS | ELI LILLY AND COMPANY (US) | 1996-02-27 | — | — | US | disclosed |
| US-5334767-A | Steroid 5a-reductase inhibitor | ELI LILLY AND COMPANY (US) | 1994-08-02 | — | — | US | disclosed |
| EP-0591583-A1 | Benzo (f) quinolinones as 5-alpha-reductase inhibitors | ELI LILLY AND COMPANY (US) | 1994-04-13 | — | — | EP | disclosed |
| EP-0591582-A1 | Hexahydrobenzo (f) quinolinones as 5-alpha-reductase inhibitors | ELI LILLY AND COMPANY (US) | 1994-04-13 | — | — | EP | disclosed |
| US-5250539-A | 5-alpha reductase inhibitors; administer as therapy for benign prostatic hyperplasia, hirsutism and acne | ELI LILLY AND COMPANY (US) | 1993-10-05 | — | — | US | disclosed |
| US-5239075-A | PROCESS FOR THE PREPARATION OF BENZO (F) QUINOLINONES | ELI LILLY AND COMPANY (US) | 1993-08-24 | — | — | US | disclosed |
| EP-0532190-A2 | Benzo f quinolinones as 5-alpha-reductase inhibitors | ELI LILLY AND COMPANY (US) | 1993-03-17 | — | — | EP | disclosed |
| EP-0531026-A1 | Hexahydrobenzo[f]quinolinones as 5-alpha-reductase inhibitors | ELI LILLY AND COMPANY (US) | 1993-03-10 | — | — | EP | disclosed |