Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Phthalic Anhydride. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.50 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.50 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | HTR6 | P50406 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 2/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phthalic Anhydride SCHEMBL7798440 | 0.88 | HTR2A (0.64) | HTR2ATAAR1CYP2A6SMN1; SMN2LOXL2 | |
| Phthalic Anhydride SCHEMBL7798012 | 0.87 | HTR2A (0.53) | HTR2ATAAR1CYP2A6SMN1; SMN2LOXL2 | |
| Phthalic Anhydride SCHEMBL7802574 | 0.87 | HTR2A (0.61) | HTR2ATAAR1CYP2A6SMN1; SMN2LOXL2 | |
| Phenethylamine SCHEMBL7798314 | 0.85 | TAAR1 (0.70) | HTR2ATAAR1CYP2A6SMN1; SMN2LOXL2 | |
| Phthalic Anhydride SCHEMBL7801507 | 0.84 | TAAR1 (0.53) | HTR2ATAAR1CYP2A6SMN1; SMN2LOXL2 | |
| Phthalic Anhydride SCHEMBL7798266 | 0.83 | HTR2A (0.57) | HTR2ATAAR1CYP2A6SMN1; SMN2LOXL2 | |
| Phthalic Anhydride SCHEMBL28176455 | 0.81 | TDP1 (0.56) | ALOX15TDP1ALDH1A1TSHRMAPK1 | |
| Phthalic Anhydride SCHEMBL7798198 | 0.81 | TDP1 (0.61) | SMN1; SMN2ALOX15TDP1ALDH1A1TSHR | |
| Phenethylamine SCHEMBL7798126 | 0.81 | HTR2A (0.46) | HTR2ATAAR1CYP2A6SMN1; SMN2LOXL2 | |
| Phenethylamine SCHEMBL7797859 | 0.81 | TAAR1 (0.46) | HTR2ATAAR1CYP2A6SMN1; SMN2LOXL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1076649-A1 | ISOQUINOLINE COMPOUND MELANOCORTIN RECEPTOR LIGANDS AND METHODS OF USING SAME | TREGA BIOSCIENCES, INC. (US) | 2001-02-21 | — | — | EP | disclosed |
| US-6127381-A | A MELANOCORTIN RECEPTOR LIGAND FOR REGULATING FOOD INTAKE AND BODY WEIGHT, REGULATING CYTOKINE ACTIVITY, ANTI-INFLAMMATORY ACTIVITY | LION BIOSCIENCE AG (DE) | 2000-10-03 | — | — | US | disclosed |
| WO-1999055679-A1 | ISOQUINOLINE COMPOUND MELANOCORTIN RECEPTOR LIGANDS AND METHODS OF USING SAME | TREGA BIOSCIENCES, INC. (US) | 1999-11-04 | — | — | WO | disclosed |