Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Lysine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIK1 | P39086 | 1/20 | 0.39 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.39 |
| ▸ | GRIK3 | Q13003 | 1/20 | 0.39 |
| ▸ | GSR | P00390 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | SLC1A5 | Q15758 | 7/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | SUV39H2 | Q9H5I1 | 1/20 | 0.35 |
| ▸ | KIF11 | P52732 | 1/20 | 0.35 |
| ▸ | ARF6 | P62330 | 1/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.35 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lysine SCHEMBL7800225 | 0.90 | SLC1A5 (0.41) | GRIK1GRIK2GRIK3GSRTDP1 | |
| Lysine SCHEMBL7802115 | 0.90 | SLC1A5 (0.41) | GRIK1GRIK2GRIK3GSRTDP1 | |
| Lysine SCHEMBL7802117 | 0.90 | SLC1A5 (0.41) | GRIK1GRIK2GRIK3GSRTDP1 | |
| Lysine SCHEMBL7798151 | 0.89 | TAAR1 (0.42) | GRIK1GRIK2GRIK3GSRTDP1 | |
| Lysine SCHEMBL7792825 | 0.89 | SLC1A5 (0.40) | GRIK1GRIK2GRIK3GSRTDP1 | |
| Lysine SCHEMBL7798547 | 0.89 | SLC1A5 (0.40) | GRIK1GRIK2GRIK3GSRTDP1 | |
| Lysine SCHEMBL7800233 | 0.88 | TDP1 (0.43) | GRIK1GRIK2GSRTDP1SLC1A5 | |
| Lysine SCHEMBL7793023 | 0.87 | SLC1A5 (0.39) | GRIK1GRIK2GRIK3GSRTDP1 | |
| Ornithine SCHEMBL7800082 | 0.87 | SLC1A5 (0.41) | GRIK1GRIK2GRIK3TDP1SLC1A5 | |
| Ornithine Aketoglutarate SCHEMBL7800084 | 0.87 | SLC1A5 (0.41) | GRIK1GRIK2GRIK3TDP1SLC1A5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1076649-A1 | ISOQUINOLINE COMPOUND MELANOCORTIN RECEPTOR LIGANDS AND METHODS OF USING SAME | TREGA BIOSCIENCES, INC. (US) | 2001-02-21 | — | — | EP | disclosed |
| US-6127381-A | A MELANOCORTIN RECEPTOR LIGAND FOR REGULATING FOOD INTAKE AND BODY WEIGHT, REGULATING CYTOKINE ACTIVITY, ANTI-INFLAMMATORY ACTIVITY | LION BIOSCIENCE AG (DE) | 2000-10-03 | — | — | US | disclosed |
| WO-1999055679-A1 | ISOQUINOLINE COMPOUND MELANOCORTIN RECEPTOR LIGANDS AND METHODS OF USING SAME | TREGA BIOSCIENCES, INC. (US) | 1999-11-04 | — | — | WO | disclosed |