Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 15/20 | 0.82 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.56 |
| ▸ | CTSS | P25774 | 2/20 | 0.52 |
| ▸ | CTSL | P07711 | 1/20 | 0.52 |
| ▸ | CTSB | P07858 | 1/20 | 0.52 |
| ▸ | CTSK | P43235 | 1/20 | 0.52 |
| ▸ | AKT1 | P31749 | 1/20 | 0.51 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.49 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.49 |
| ▸ | PSMB9 | P28065 | 1/20 | 0.49 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7680706 | 0.99 | PTPN1 (0.83) | PTPN1PTPN22CTSSCTSLCTSB | |
| SCHEMBL7673490 | 0.94 | PTPN1 (0.86) | PTPN1PTPN22CTSSCTSLCTSB | |
| SCHEMBL6572424 | 0.94 | PTPN1 (0.88) | PTPN1PTPN22CTSS | |
| SCHEMBL7676519 | 0.93 | PTPN1 (0.76) | PTPN1PTPN22CTSSCTSLCTSB | |
| SCHEMBL7672386 | 0.92 | PTPN1 (0.83) | PTPN1PTPN22CTSSCTSLCTSB | |
| SCHEMBL7671723 | 0.91 | PTPN1 (0.86) | PTPN1PTPN22CTSSCTSLCTSB | |
| SCHEMBL7693854 | 0.91 | PTPN1 (0.80) | PTPN1PTPN22CTSSCTSLCTSB | |
| SCHEMBL7693851 | 0.91 | PTPN1 (0.80) | PTPN1PTPN22CTSSCTSLCTSB | |
| SCHEMBL7680961 | 0.91 | PTPN1 (0.75) | PTPN1PTPN22CTSSCTSLCTSB | |
| SCHEMBL7680978 | 0.90 | PTPN1 (0.85) | PTPN1PTPN22CTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1161421-A1 | INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE | Pharmacia & Upjohn Aktiebolag (SE) | 2001-12-12 | — | — | EP | disclosed |
| WO-2000053583-A1 | INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE | BIOVITRUM AB (SE) | 2000-09-14 | — | — | WO | disclosed |