Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | PDE4A | P27815 | 9/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 8/20 | 0.48 |
| ▸ | PDE4C | Q08493 | 8/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 8/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7793007 | 0.94 | PDE4B (0.53) | MEN1KMT2APDE4APDE4BPDE4C | |
| SCHEMBL7801997 | 0.90 | PDE4B (0.47) | MEN1KMT2APDE4APDE4BPDE4C | |
| SCHEMBL6657114 | 0.88 | PDE4B (0.56) | MEN1KMT2APOLBPDE4APDE4B | |
| SCHEMBL7798507 | 0.86 | NPC1 (0.48) | MEN1KMT2APOLBPDE4APDE4B | |
| SCHEMBL7802771 | 0.85 | PDE4B (0.55) | MEN1KMT2APDE4APDE4BPDE4C | |
| SCHEMBL7801784 | 0.85 | PDE4A (0.53) | POLBPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7802859 | 0.85 | PDE4A (0.49) | POLBPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL27592843 | 0.85 | PDE4A (0.51) | POLBPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7798476 | 0.85 | PDE4A (0.49) | POLBPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7801812 | 0.85 | PDE4A (0.52) | MEN1KMT2APOLBPDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0723962-B1 | Arylalkyl-thiadiazinones | MERCK PATENT GMBH (DE) | 2001-07-04 | — | — | EP | disclosed |
| US-6025354-A | Arylalkyl-thiadiazinones | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-02-15 | — | — | US | disclosed |
| US-5747489-A | Arylalkyl-thiadiazinones | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1998-05-05 | — | — | US | disclosed |
| EP-0723962-A1 | Arylalkyl-thiadiazinones | MERCK PATENT GmbH (DE) | 1996-07-31 | — | — | EP | disclosed |