Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 13/20 | 0.57 |
| ▸ | SMO | Q99835 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | SETD2 | Q9BYW2 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6476817 | 0.94 | MAPK14 (0.63) | MAPK14SMOMAPTPOLBRAB9A | |
| SCHEMBL7780464 | 0.91 | MAPK14 (0.65) | MAPK14SMOMAPTPOLBSETD2 | |
| SCHEMBL7809438 | 0.87 | MAPK14 (0.59) | MAPK14SMOMAPTPOLBSETD2 | |
| SCHEMBL7805605 | 0.87 | MAPK14 (0.61) | MAPK14SMOMAPTSETD2HTT | |
| SCHEMBL7110831 | 0.86 | POLB (0.54) | MAPK14GAAMAPTPOLBHTT | |
| SCHEMBL6533294 | 0.85 | MAPK14 (0.63) | MAPK14SMOMAPTPOLBRAB9A | |
| SCHEMBL7804583 | 0.84 | MAPK14 (0.62) | MAPK14SMOMAPTSETD2RAB9A | |
| SCHEMBL6782804 | 0.83 | MAPK14 (0.73) | MAPK14SMOMAPTSETD2HTT | |
| SCHEMBL7804599 | 0.83 | MAPT (0.59) | MAPK14SMOGAAMAPTPOLB | |
| SCHEMBL6487599 | 0.82 | MAPK14 (0.61) | MAPK14SMOMAPTPOLBRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1077931-A1 | BENZAMIDE DERIVATIVES FOR THE TREATMENT OF DISEASES MEDIATED BY CYTOKINES | AstraZeneca AB (SE) | 2001-02-28 | — | — | EP | disclosed |
| WO-1999059959-A1 | BENZAMIDE DERIVATIVES FOR THE TREATMENT OF DISEASES MEDIATED BY CYTOKINES | ASTRAZENECA AB (SE) | 1999-11-25 | — | — | WO | disclosed |