Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 20/20 | 0.62 |
| ▸ | KDR | P35968 | 5/20 | 0.62 |
| ▸ | KIT | P10721 | 3/20 | 0.62 |
| ▸ | INSR | P06213 | 2/20 | 0.60 |
| ▸ | ABL1 | P00519 | 1/20 | 0.51 |
| ▸ | IGF1R | P08069 | 1/20 | 0.51 |
| ▸ | MET | P08581 | 1/20 | 0.51 |
| ▸ | SRC | P12931 | 1/20 | 0.51 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7807812 | 0.89 | ALK (0.64) | ALKKDRKITINSRABL1 | |
| SCHEMBL7805824 | 0.89 | ALK (0.75) | ALKKDRKITINSRABL1 | |
| SCHEMBL7816141 | 0.86 | ALK (0.66) | ALKKDRKITINSR | |
| SCHEMBL7809601 | 0.85 | ALK (0.79) | ALKKDRKITINSR | |
| SCHEMBL7806453 | 0.85 | ALK (0.67) | ALKKDRKITINSR | |
| SCHEMBL7805826 | 0.84 | ALK (0.74) | ALKKDRKITINSR | |
| SCHEMBL7816380 | 0.84 | ALK (0.68) | ALKKDRKITINSR | |
| SCHEMBL7807873 | 0.84 | ALK (0.65) | ALKKDRKITINSR | |
| SCHEMBL7812981 | 0.84 | ALK (0.69) | ALKKDRKITINSR | |
| SCHEMBL7806236 | 0.83 | ALK (0.63) | ALKKDRKITINSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010143664-A1 | TETRACYCLIC COMPOUND | 中外製薬株式会社 (JP) | 2010-12-16 | — | — | WO | disclosed |