Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 12/20 | 0.50 |
| ▸ | PDE4B | Q07343 | 12/20 | 0.50 |
| ▸ | PDE4C | Q08493 | 12/20 | 0.50 |
| ▸ | PDE4D | Q08499 | 12/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.45 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7798641 | 0.92 | PDE4D (0.57) | PDE4APDE4BPDE4CPDE4DNPC1 | |
| SCHEMBL7800697 | 0.87 | PDE4A (0.52) | PDE4APDE4BPDE4CPDE4DNPC1 | |
| SCHEMBL7801812 | 0.87 | PDE4A (0.52) | PDE4APDE4BPDE4CPDE4DHPGD | |
| SCHEMBL7802694 | 0.87 | PDE4D (0.51) | PDE4APDE4BPDE4CPDE4DNPC1 | |
| SCHEMBL6654207 | 0.86 | PDE4A (0.51) | PDE4APDE4BPDE4CPDE4DNPC1 | |
| SCHEMBL7800731 | 0.86 | PDE4D (0.51) | PDE4APDE4BPDE4CPDE4DNPC1 | |
| SCHEMBL7800669 | 0.85 | PDE4D (0.50) | PDE4APDE4BPDE4CPDE4DNPC1 | |
| SCHEMBL7800589 | 0.85 | PDE4A (0.50) | PDE4APDE4BPDE4CPDE4DNPC1 | |
| SCHEMBL7802879 | 0.85 | PDE4D (0.50) | PDE4APDE4BPDE4CPDE4DNPC1 | |
| SCHEMBL7798599 | 0.85 | PDE4D (0.50) | PDE4APDE4BPDE4CPDE4DNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0723962-B1 | Arylalkyl-thiadiazinones | MERCK PATENT GMBH (DE) | 2001-07-04 | — | — | EP | disclosed |
| US-6025354-A | Arylalkyl-thiadiazinones | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-02-15 | — | — | US | disclosed |
| US-5747489-A | Arylalkyl-thiadiazinones | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1998-05-05 | — | — | US | disclosed |
| EP-0723962-A1 | Arylalkyl-thiadiazinones | MERCK PATENT GmbH (DE) | 1996-07-31 | — | — | EP | disclosed |