Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 13/20 | 0.78 |
| ▸ | HTR1B | P28222 | 10/20 | 0.78 |
| ▸ | HTR2A | P28223 | 4/20 | 0.78 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.65 |
| ▸ | TMPRSS2 | O15393 | 1/20 | 0.65 |
| ▸ | RAB9A | P51151 | 2/20 | 0.59 |
| ▸ | NPC1 | O15118 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | HTR1A | P08908 | 7/20 | 0.58 |
| ▸ | HTR2C | P28335 | 3/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.58 |
| ▸ | LCK | P06239 | 1/20 | 0.58 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.58 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.58 |
| ▸ | HTR3B | O95264 | 1/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7803371 | 0.88 | HTR1D (1.00) | HTR1DHTR1BHTR2ASLC6A4TMPRSS2 | |
| SCHEMBL4688960 | 0.87 | HTR1D (0.68) | HTR1DHTR1BHTR2ASLC6A4TMPRSS2 | |
| SCHEMBL9299637 | 0.85 | HTR1D (0.62) | HTR1DHTR1BHTR2ASLC6A4TMPRSS2 | |
| SCHEMBL8985970 | 0.83 | HTR1D (0.92) | HTR1DHTR1BHTR2ASLC6A4TMPRSS2 | |
| SCHEMBL9300006 | 0.83 | HTR1D (0.81) | HTR1DHTR1BHTR2ASLC6A4TMPRSS2 | |
| SCHEMBL8705195 | 0.83 | HTR1D (0.70) | HTR1DHTR1BHTR2ASLC6A4TMPRSS2 | |
| SCHEMBL7805150 | 0.83 | HTR1D (0.77) | HTR1DHTR1BHTR2ASLC6A4TMPRSS2 | |
| SCHEMBL8705402 | 0.83 | HTR1D (0.70) | HTR1DHTR1BHTR2ASLC6A4TMPRSS2 | |
| SCHEMBL8704883 | 0.83 | HTR1D (0.70) | HTR1DHTR1BHTR2ASLC6A4TMPRSS2 | |
| SCHEMBL29611473 | 0.82 | HTR1D (0.77) | HTR1DHTR1BHTR2ASLC6A4TMPRSS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0533268-B1 | Benzanilide derivatives as 5-HT1D antagonists | GLAXO GROUP LTD (GB) | 2001-08-16 | — | — | EP | disclosed |
| US-5356893-A | Antidepressants, nervous system disorders | GLAXO GROUP LIMITED (GB) | 1994-10-18 | — | — | US | disclosed |
| US-5340810-A | Useful in the treatment and prophylaxis of depression and other disorders of the central nervous system | GLAXO GROUP LIMITED (GB) | 1994-08-23 | — | — | US | disclosed |
| EP-0533266-A1 | Benzanilide derivatives as 5-HT1D antagonists | GLAXO GROUP LIMITED (GB) | 1993-03-24 | — | — | EP | disclosed |