Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 11/20 | 0.78 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.71 |
| ▸ | HTR1B | P28222 | 4/20 | 0.71 |
| ▸ | HTR1A | P08908 | 3/20 | 0.71 |
| ▸ | MEN1 | O00255 | 2/20 | 0.71 |
| ▸ | MAPT | P10636 | 2/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.71 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.71 |
| ▸ | HTR2A | P28223 | 2/20 | 0.71 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.71 |
| ▸ | HTR3B | O95264 | 1/20 | 0.71 |
| ▸ | TP53 | P04637 | 1/20 | 0.71 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.71 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.71 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.71 |
| ▸ | TSHR | P16473 | 1/20 | 0.71 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.71 |
| ▸ | HTR2C | P28335 | 1/20 | 0.71 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.71 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9563411 | 0.95 | HTR1D (0.71) | HTR1DSLC6A4HTR1BHTR1AMEN1 | |
| SCHEMBL5319425 | 0.88 | HTR1D (1.00) | HTR1DSLC6A4HTR1BHTR1AMEN1 | |
| SCHEMBL9435224 | 0.87 | HTR1D (0.76) | HTR1DSLC6A4HTR1BHTR1AMEN1 | |
| SCHEMBL9435227 | 0.85 | HTR1D (0.78) | HTR1DSLC6A4HTR1BHTR1AMEN1 | |
| SCHEMBL7795214 | 0.85 | HTR1D (0.78) | HTR1DSLC6A4HTR1BHTR1AMEN1 | |
| SCHEMBL9300606 | 0.84 | HTR1D (0.86) | HTR1DSLC6A4HTR1BHTR1AMEN1 | |
| SCHEMBL9089859 | 0.84 | HTR1D (0.76) | HTR1DSLC6A4HTR1BHTR1AMEN1 | |
| SCHEMBL9091365 | 0.84 | HTR1D (0.84) | HTR1DSLC6A4HTR1BHTR1AMEN1 | |
| SCHEMBL9301061 | 0.84 | HTR1D (0.81) | HTR1DSLC6A4HTR1BHTR1AMEN1 | |
| SCHEMBL9295861 | 0.83 | LCK (0.59) | HTR1DSLC6A4HTR1BHTR1AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0533268-B1 | Benzanilide derivatives as 5-HT1D antagonists | GLAXO GROUP LTD (GB) | 2001-08-16 | — | — | EP | disclosed |
| US-5510350-A | USEFUL IN TREATMENT OR PROPHYLAXIS OF DEPRESSION AND OTHER CENTRAL NERVOUS SYSTEM DISORDERS | GLAXO GROUP LIMITED (GB) | 1996-04-23 | — | — | US | disclosed |
| US-5340810-A | Useful in the treatment and prophylaxis of depression and other disorders of the central nervous system | GLAXO GROUP LIMITED (GB) | 1994-08-23 | — | — | US | disclosed |