Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 17/20 | 0.46 |
| ▸ | PDE4A | P27815 | 16/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 16/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 16/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.39 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7801934 | 0.93 | PDE4D (0.46) | PDE4DPDE4APDE4BPDE4CTP53 | |
| SCHEMBL7798492 | 0.91 | PDE4D (0.47) | PDE4DPDE4APDE4BPDE4CPDE3B | |
| SCHEMBL7800586 | 0.91 | PDE4D (0.47) | PDE4DPDE4APDE4BPDE4CPDE3B | |
| SCHEMBL7802039 | 0.91 | PDE4D (0.47) | PDE4DPDE4APDE4BPDE4CPDE3B | |
| SCHEMBL7800707 | 0.91 | PDE4D (0.49) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL7802858 | 0.91 | PDE4D (0.47) | PDE4DPDE4APDE4BPDE4CPDE3B | |
| SCHEMBL7800757 | 0.90 | PDE4D (0.46) | PDE4DPDE4APDE4BPDE4CPDE3B | |
| SCHEMBL7798590 | 0.89 | PDE4D (0.45) | PDE4DPDE4APDE4BPDE4CPDE3B | |
| SCHEMBL7800686 | 0.89 | PDE4A (0.45) | PDE4DPDE4APDE4BPDE4CPDE3B | |
| SCHEMBL7793014 | 0.89 | PDE4D (0.45) | PDE4DPDE4APDE4BPDE4CTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0723962-B1 | Arylalkyl-thiadiazinones | MERCK PATENT GMBH (DE) | 2001-07-04 | — | — | EP | disclosed |
| US-6025354-A | Arylalkyl-thiadiazinones | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-02-15 | — | — | US | disclosed |
| US-5747489-A | Arylalkyl-thiadiazinones | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1998-05-05 | — | — | US | disclosed |
| EP-0723962-A1 | Arylalkyl-thiadiazinones | MERCK PATENT GmbH (DE) | 1996-07-31 | — | — | EP | disclosed |