Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 9/20 | 0.50 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.50 |
| ▸ | PDE4A | P27815 | 4/20 | 0.50 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.50 |
| ▸ | MET | P08581 | 3/20 | 0.50 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.50 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | CFTR | P13569 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7802051 | 0.94 | PDE4B (0.53) | PDE4BPDE4DPDE4APDE4CMET | |
| SCHEMBL7802782 | 0.94 | PDE4B (0.51) | PDE4BPDE4DPDE4APDE4CMET | |
| SCHEMBL7792954 | 0.91 | PDE4B (0.52) | PDE4BPDE4DPDE4APDE4CMET | |
| SCHEMBL7802000 | 0.88 | PDE4B (0.58) | PDE4BPDE4DPDE4APDE4CMET | |
| SCHEMBL7802780 | 0.88 | PDE4B (0.54) | PDE4BPDE4DPDE4APDE4CMET | |
| SCHEMBL7798602 | 0.88 | PDE4B (0.54) | PDE4BPDE4DPDE4APDE4CMET | |
| SCHEMBL141325 | 0.88 | PDE4B (0.56) | PDE4BPDE4DPDE4APDE4CPDE3B | |
| SCHEMBL7798702 | 0.88 | PDE4A (0.46) | PDE4BPDE4DPDE4APDE4CMET | |
| SCHEMBL7802920 | 0.88 | PDE4B (0.53) | PDE4BPDE4DPDE4APDE4CMET | |
| SCHEMBL7798625 | 0.87 | PDE4B (0.54) | PDE4BPDE4DPDE4APDE4CMET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0723962-B1 | Arylalkyl-thiadiazinones | MERCK PATENT GMBH (DE) | 2001-07-04 | — | — | EP | disclosed |
| US-6025354-A | Arylalkyl-thiadiazinones | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-02-15 | — | — | US | disclosed |
| US-5747489-A | Arylalkyl-thiadiazinones | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1998-05-05 | — | — | US | disclosed |
| EP-0723962-A1 | Arylalkyl-thiadiazinones | MERCK PATENT GmbH (DE) | 1996-07-31 | — | — | EP | disclosed |