Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR2 | P21452 | 11/20 | 0.65 |
| ▸ | TACR1 | P25103 | 7/20 | 0.65 |
| ▸ | CCR5 | P51681 | 1/20 | 0.55 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.51 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.51 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7812116 | 0.87 | TACR2 (0.67) | TACR2TACR1 | |
| Hydrochloric Acid SCHEMBL7871923 | 0.84 | TACR2 (0.69) | TACR2TACR1CCR5 | |
| SCHEMBL8479506 | 0.83 | TACR2 (0.72) | TACR2TACR1CCR5 | |
| Hydrochloric Acid SCHEMBL9317668 | 0.82 | TACR2 (0.83) | TACR2TACR1CCR5 | |
| SCHEMBL6952533 | 0.80 | TACR2 (0.61) | TACR2TACR1SLC6A2SLC6A4SLC6A3 | |
| Hydrochloric Acid SCHEMBL9317762 | 0.80 | TACR2 (0.65) | TACR2TACR1 | |
| SCHEMBL7870017 | 0.79 | TACR2 (0.61) | TACR2TACR1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL8588638 | 0.79 | TACR2 (0.69) | TACR2TACR1 | |
| SCHEMBL8870973 | 0.79 | TACR2 (1.00) | TACR2TACR1 | |
| SCHEMBL7024567 | 0.79 | TACR2 (0.52) | TACR2TACR1CCR5SLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0773929-B1 | PIPERIDINE DERIVATIVES AS NEUROKININ ANTAGONISTS | SCHERING CORP (US) | 2001-10-31 | — | — | EP | disclosed |
| US-5654316-A | Piperidine derivatives as neurokinin antagonists | SCHERING CORPORATION (US) | 1997-08-05 | — | — | US | disclosed |