Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.33 |
| ▸ | TYMP | P19971 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.32 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.31 |
| ▸ | ATR | Q13535 | 1/20 | 0.31 |
| ▸ | ELANE | P08246 | 1/20 | 0.31 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.31 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9887300 | 0.86 | — | — | |
| SCHEMBL3502363 | 0.75 | TYMP (0.41) | ALDH1A1CYP3A4JAK2JAK1JAK3 | |
| SCHEMBL2105114 | 0.75 | TYMP (0.41) | ALDH1A1CYP3A4JAK2JAK1JAK3 | |
| SCHEMBL18244172 | 0.75 | TYMP (0.41) | ALDH1A1CYP3A4JAK2JAK1JAK3 | |
| SCHEMBL18244171 | 0.75 | TYMP (0.41) | ALDH1A1CYP3A4JAK2JAK1JAK3 | |
| SCHEMBL3233362 | 0.75 | TYMP (0.41) | ALDH1A1CYP3A4JAK2JAK1JAK3 | |
| SCHEMBL21057468 | 0.75 | TYMP (0.41) | ALDH1A1CYP3A4JAK2JAK1JAK3 | |
| SCHEMBL3233355 | 0.75 | TYMP (0.41) | ALDH1A1CYP3A4JAK2JAK1JAK3 | |
| SCHEMBL11201526 | 0.75 | TYMP (0.41) | ALDH1A1CYP3A4JAK2JAK1JAK3 | |
| SCHEMBL3796623 | 0.75 | TYMP (0.41) | ALDH1A1CYP3A4JAK2JAK1JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1385422-A | Process for preparing 2-azadihydroxybicyclo [2.2.1] heptane compounds | AVENTIS PHARMA INC (US) | 2002-12-18 | — | — | CN | disclosed |
| CN-1094927-C | Process for preparing 2-azadihydroxybicyclo [2.2.1] heptane compounds and L-tartrate salts of such compounds | AVENTIS PHARMACEUTICAL CORP (US) | 2002-11-27 | — | — | CN | disclosed |
| EP-0934268-A4 | PROCESS FOR PREPARING 2-AZADIHYDROXYBICYCLO 2.2.1]HEPTANE COMPOUNDS AND THE L-TARTARIC ACID SALT OF THE COMPOUND | RHONE POULENC RORER PHARMA (US) | 2001-04-18 | — | — | EP | disclosed |
| CN-1233239-A | Process for preparing 2-azadihydroxybicyclo [2.2.1] heptane compounds and L-tartrate salts of such compounds | RHONE POULENC RORER PHARMA (US) | 1999-10-27 | — | — | CN | disclosed |
| EP-0934268-A1 | PROCESS FOR PREPARING 2-AZADIHYDROXYBICYCLO 2.2.1]HEPTANE COMPOUNDS AND THE L-TARTARIC ACID SALT OF THE COMPOUND | RHONE-POULENC RORER PHARMACEUTICALS, INC. (US) | 1999-08-11 | — | — | EP | disclosed |
| US-5886192-A | L-tartaric acid salt of a (1R) diastereomer of a 2-azadihydroxybicyclo 2.2.1!heptane compound and the preparation of 2-azabicyclo 2.2.1!heptane compounds | RHONE-POULENC RORER S.A. (FR) | 1999-03-23 | — | — | US | disclosed |
| US-5831096-A | L-tartaric acid salt of a (1R) diastereomer of a 2-azadihydroxybicyclo 2.2.1!heptane compound and the preparation of 2-azabicyclo 2.2.1! heptane compounds | RHONE-POULENC RORER S.A. (FR) | 1998-11-03 | — | — | US | disclosed |
| US-5808093-A | L-tartaric acid salt of a (1R) diastereomer of a 2-azadihydroxybicyclo 2.2.1!heptane compound and the preparation of 2-azabicyclo 2.2.1!heptane compounds | RHONE-POULENC RORER S.A. (FR) | 1998-09-15 | — | — | US | disclosed |
| WO-1998016510-A1 | PROCESS FOR PREPARING 2-AZADIHYDROXYBICYCLO[2.2.1]HEPTANE COMPOUNDS AND THE L-TARTARIC ACID SALT OF THE COMPOUND | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1998-04-23 | — | — | WO | disclosed |
| US-5684159-A | L-tartaric acid salt of a (1R) diastereomer of a 2-azadihydroxybicyclo 2.2.1!heptane compound and the preparation of 2-azabicyclo 2.2.1!heptane compounds | RHONE-POULENC RORER S.A. (FR) | 1997-11-04 | — | — | US | disclosed |