Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 6/20 | 0.62 |
| ▸ | CDK2 | P24941 | 4/20 | 0.62 |
| ▸ | MAPT | P10636 | 3/20 | 0.62 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.62 |
| ▸ | CDK5R1 | Q15078 | 3/20 | 0.62 |
| ▸ | SMG1 | Q96Q15 | 3/20 | 0.62 |
| ▸ | MTOR | P42345 | 2/20 | 0.62 |
| ▸ | NPC1 | O15118 | 2/20 | 0.62 |
| ▸ | XBP1 | P17861 | 2/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.62 |
| ▸ | HTT | P42858 | 2/20 | 0.62 |
| ▸ | RAB9A | P51151 | 2/20 | 0.62 |
| ▸ | CDK4 | P11802 | 2/20 | 0.62 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.62 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.62 |
| ▸ | CCND1 | P24385 | 2/20 | 0.62 |
| ▸ | CDK7 | P50613 | 2/20 | 0.62 |
| ▸ | CCNH | P51946 | 2/20 | 0.62 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.62 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3511867 | 0.92 | CDK1 (0.72) | CDK1CDK2MAPTCDK5CDK5R1 | |
| Hydrochloric Acid SCHEMBL7804186 | 0.89 | ABL1 (0.56) | CDK1CDK2MAPTCDK5CDK5R1 | |
| SCHEMBL7809524 | 0.87 | ABL1 (0.64) | CDK1CDK2MAPTCDK5CDK5R1 | |
| SCHEMBL3513566 | 0.86 | MAPT (0.66) | CDK1CDK2MAPTCDK5CDK5R1 | |
| Hydrochloric Acid SCHEMBL3515325 | 0.86 | ABL1 (0.62) | CDK1CDK2MAPTCDK5CDK5R1 | |
| Monoethanolamine SCHEMBL7813293 | 0.85 | CSNK2A1 (0.63) | CDK1CDK2MAPTCDK5CDK5R1 | |
| SCHEMBL7809816 | 0.85 | CSNK2A1 (0.68) | CDK1CDK2MAPTCDK5CDK5R1 | |
| SCHEMBL8837844 | 0.84 | CSNK2A1 (0.68) | CDK1CDK2MAPTCDK5CDK5R1 | |
| SCHEMBL3512675 | 0.84 | MAPT (0.58) | CDK1CDK2MAPTCDK5CDK5R1 | |
| Hydrochloric Acid SCHEMBL3514073 | 0.84 | CSNK2A1 (0.67) | CDK1CDK2MAPTCDK5CDK5R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0672041-B1 | PHARMACOLOGICALLY ACTIVE PYRIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF | NOVARTIS AG (CH) | 2001-11-14 | — | — | EP | disclosed |
| EP-0672041-A1 | PHARMACOLOGICALLY ACTIVE PYRIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF | Novartis AG (CH) | 1995-09-20 | — | — | EP | disclosed |
| WO-1995009853-A1 | PHARMACOLOGICALLY ACTIVE PYRIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF | CIBA-GEIGY AG (CH) | 1995-04-13 | — | — | WO | disclosed |