Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 8/20 | 0.66 |
| ▸ | CYP11B2 | P19099 | 8/20 | 0.66 |
| ▸ | TNF | P01375 | 1/20 | 0.66 |
| ▸ | HTT | P42858 | 5/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7814283 | 0.88 | CYP11B1 (0.66) | CYP11B1CYP11B2TNFHTTSMN1; SMN2 | |
| SCHEMBL3962695 | 0.81 | CYP11B1 (0.75) | CYP11B1CYP11B2TNFHTTSMN1; SMN2 | |
| SCHEMBL28711279 | 0.80 | CYP11B1 (0.69) | CYP11B1CYP11B2TNFHTTSMN1; SMN2 | |
| SCHEMBL230002 | 0.80 | CYP11B1 (1.00) | CYP11B1CYP11B2TNFHTTSMN1; SMN2 | |
| SCHEMBL31357411 | 0.80 | CYP11B1 (1.00) | CYP11B1CYP11B2TNFHTTSMN1; SMN2 | |
| SCHEMBL9557677 | 0.77 | NPC1 (0.41) | CYP11B1CYP11B2HTTSMN1; SMN2LMNA | |
| SCHEMBL13907295 | 0.74 | CYP11B1 (0.89) | CYP11B1CYP11B2TNFHTTSMN1; SMN2 | |
| SCHEMBL27839811 | 0.74 | CYP11B1 (0.87) | CYP11B1CYP11B2TNFHTTSMN1; SMN2 | |
| SCHEMBL27699770 | 0.74 | CYP11B1 (0.87) | CYP11B1CYP11B2TNFHTTSMN1; SMN2 | |
| SCHEMBL28610944 | 0.73 | CYP11B1 (0.84) | CYP11B1CYP11B2TNFHTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0745600-B1 | Benzimidazole derivatives, their preparation and their therapeutic use | SANKYO CO (JP) | 2001-10-24 | — | — | EP | disclosed |
| US-5886014-A | TREATMENT AND/OR PROPHYLAXIS OF A VARIETY OF DISORDERS, INCLUDING HYPERLIPEMIA, HYPERGLYCEMIA, OBESITY, IMPAIRED GLUCOSE TOLERANCE (IGT), INSULIN RESISTANCE AND DIABETIC COMPLICATIONS | SANKYO COMPANY, LIMITED (JP) | 1999-03-23 | — | — | US | disclosed |
| EP-0745600-A1 | Benzimidazole derivatives, their preparation and their therapeutic use | SANKYO COMPANY LIMITED (JP) | 1996-12-04 | — | — | EP | disclosed |