Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 20/20 | 0.63 |
| ▸ | BRD4 | O60885 | 4/20 | 0.63 |
| ▸ | BRDT | Q58F21 | 3/20 | 0.63 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.55 |
| ▸ | RAF1 | P04049 | 1/20 | 0.55 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.55 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.55 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4584672 | 0.95 | MAPK14 (0.60) | MAPK14BRD4BRDTMAPK13RAF1 | |
| SCHEMBL4585317 | 0.93 | MAPK14 (0.63) | MAPK14BRD4BRDTMAPK13RAF1 | |
| SCHEMBL4583854 | 0.91 | MAPK14 (0.63) | MAPK14BRD4BRDTMAPK13RAF1 | |
| SCHEMBL4584142 | 0.91 | MAPK14 (0.63) | MAPK14BRD4BRDTMAPK13RAF1 | |
| SCHEMBL4585291 | 0.91 | MAPK14 (0.63) | MAPK14BRD4BRDTMAPK13RAF1 | |
| SCHEMBL4586526 | 0.91 | MAPK14 (0.61) | MAPK14BRD4BRDTMAPK13RAF1 | |
| SCHEMBL7811844 | 0.90 | MAPK14 (0.64) | MAPK14BRD4BRDTMAPK13RAF1 | |
| SCHEMBL4584970 | 0.90 | MAPK14 (0.64) | MAPK14BRD4BRDTMAPK13RAF1 | |
| SCHEMBL4585692 | 0.89 | MAPK14 (0.64) | MAPK14BRD4BRDTMAPK13RAF1 | |
| SCHEMBL4584883 | 0.89 | MAPK14 (0.65) | MAPK14BRD4BRDTMAPK13RAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0996446-A4 | NOVEL SUBSTITUTED IMIDAZOLE COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2001-08-29 | — | — | EP | claimed |
| EP-0996446-A1 | NOVEL SUBSTITUTED IMIDAZOLE COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-05-03 | — | — | EP | claimed |
| WO-1999001131-A1 | NOVEL SUBSTITUTED IMIDAZOLE COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1999-01-14 | — | — | WO | claimed |