Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LDLR | P01130 | 11/20 | 0.58 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.43 |
| ▸ | KIT | P10721 | 1/20 | 0.43 |
| ▸ | BCHE | P06276 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6488218 | 0.88 | LDLR (0.75) | LDLRNPC1 | |
| SCHEMBL6477342 | 0.88 | LDLR (0.71) | LDLRMAPK14NPC1 | |
| SCHEMBL6486131 | 0.86 | LDLR (0.78) | LDLRNPC1 | |
| SCHEMBL6786471 | 0.82 | LDLR (0.74) | LDLRMAPK11MAPK14KITHDAC6 | |
| SCHEMBL6477653 | 0.76 | BCHE (0.53) | MAPK11MAPK14BCHENPC1HDAC8 | |
| SCHEMBL6476046 | 0.74 | BCHE (0.49) | BCHENPC1 | |
| SCHEMBL6781245 | 0.73 | LDLR (1.00) | LDLRMAPK11MAPK14NPC1HDAC6 | |
| SCHEMBL6778422 | 0.73 | LDLR (1.00) | LDLRNPC1 | |
| SCHEMBL6484244 | 0.73 | NPC1 (0.50) | MAPK11MAPK14BCHENPC1HDAC8 | |
| SCHEMBL6483995 | 0.73 | MAPK14 (0.60) | MAPK14BCHENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1077931-A1 | BENZAMIDE DERIVATIVES FOR THE TREATMENT OF DISEASES MEDIATED BY CYTOKINES | AstraZeneca AB (SE) | 2001-02-28 | — | — | EP | disclosed |
| WO-1999059959-A1 | BENZAMIDE DERIVATIVES FOR THE TREATMENT OF DISEASES MEDIATED BY CYTOKINES | ASTRAZENECA AB (SE) | 1999-11-25 | — | — | WO | disclosed |