Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 8/20 | 0.59 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.51 |
| ▸ | FNTA | P49354 | 1/20 | 0.47 |
| ▸ | FNTB | P49356 | 1/20 | 0.47 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9545015 | 0.90 | ACE (0.56) | ACEABCB11FNTAFNTBPGGT1B | |
| SCHEMBL27726228 | 0.90 | ACE (0.56) | ACEABCB11FNTAFNTBPGGT1B | |
| SCHEMBL27726229 | 0.90 | ACE (0.56) | ACEABCB11FNTAFNTBPGGT1B | |
| SCHEMBL9545013 | 0.90 | ACE (0.56) | ACEABCB11FNTAFNTBPGGT1B | |
| SCHEMBL3728963 | 0.84 | XIAP (0.61) | ACE | |
| SCHEMBL15569217 | 0.84 | XIAP (0.61) | ACE | |
| SCHEMBL29670215 | 0.83 | ACE (0.51) | ACEABCB11 | |
| SCHEMBL27726218 | 0.82 | ACE (0.55) | ACEABCB11POLB | |
| SCHEMBL27726298 | 0.82 | HDAC8 (0.52) | ACEFNTAFNTBPGGT1B | |
| SCHEMBL27726215 | 0.82 | ACE (0.55) | ACEABCB11POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1114822-A2 | Indoles and tetrahydroisoquinolines containing alpha-keto oxadiazoles as serine protease inhibitors | Cortech Inc. (US) | 2001-07-11 | — | — | EP | disclosed |
| US-6100238-A | USEFUL AS INHIBITORS OF HUMAN NEUTROPHIL ELASTASE (HNE) FOR THE TREATMENT OF HNE-MEDIATED PROCESSES IMPLICATED IN CONDITIONS SUCH AS ADULT RESPIRATORY DISTRESS SYNDROME, SEPTIC SHOCK AND MULTIPLE ORGAN FAILURE | CORTECH INC. (US) | 2000-08-08 | — | — | US | disclosed |