Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 18/20 | 0.89 |
| ▸ | KDR | P35968 | 3/20 | 0.89 |
| ▸ | FBP1 | P09467 | 2/20 | 0.89 |
| ▸ | AURKA | O14965 | 1/20 | 0.89 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.89 |
| ▸ | INSR | P06213 | 1/20 | 0.89 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.89 |
| ▸ | FLT4 | P35916 | 1/20 | 0.89 |
| ▸ | CLK1 | P49759 | 1/20 | 0.89 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.89 |
| ▸ | TEK | Q02763 | 1/20 | 0.89 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.89 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30505605 | 0.94 | EGFR (1.00) | EGFRKDRFBP1AURKAERBB2 | |
| SCHEMBL2099106 | 0.94 | EGFR (1.00) | EGFRKDRFBP1AURKAERBB2 | |
| Hydrochloric Acid SCHEMBL27887194 | 0.93 | EGFR (0.98) | EGFRKDRFBP1AURKAERBB2 | |
| SCHEMBL7814811 | 0.93 | EGFR (0.89) | EGFRKDRFBP1AURKAERBB2 | |
| Hydrochloric Acid SCHEMBL7811119 | 0.92 | EGFR (0.87) | EGFRKDRFBP1AURKAERBB2 | |
| SCHEMBL17520369 | 0.91 | EGFR (0.85) | EGFRKDRFBP1AURKAERBB2 | |
| SCHEMBL3238800 | 0.90 | EGFR (0.83) | EGFRKDRFBP1AURKAERBB2 | |
| SCHEMBL21982432 | 0.89 | EGFR (0.89) | EGFRKDRFBP1AURKAERBB2 | |
| SCHEMBL8213640 | 0.88 | EGFR (0.85) | EGFRKDRFBP1AURKAERBB2 | |
| SCHEMBL24413913 | 0.88 | EGFR (0.87) | EGFRKDRFBP1AURKAERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0635498-B1 | Quinazoline derivatives and their use as anti-cancer agents | SYNGENTA LTD (GB) | 2001-04-18 | — | — | EP | disclosed |
| US-5475001-A | Quinazoline derivatives | ZENECA LIMITED (GB) | 1995-12-12 | — | — | US | disclosed |
| WO-1995003283-A1 | QUINAZOLINE DERIVATIVES AND THEIR USE AS ANTI-CANCER AGENTS | ZENECA LIMITED (GB) | 1995-02-02 | — | — | WO | disclosed |
| EP-0635498-A1 | Quinazoline derivatives and their use as anti-cancer agents | ZENECA LIMITED (GB) | 1995-01-25 | — | — | EP | disclosed |