Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 11/20 | 0.56 |
| ▸ | MEN1 | O00255 | 10/20 | 0.56 |
| ▸ | MAPT | P10636 | 7/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | MMP14 | P50281 | 1/20 | 0.42 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.42 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.42 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA4 | P22748 | 1/20 | 0.41 |
| ▸ | CA7 | P43166 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31071661 | 0.85 | KMT2A (0.58) | KMT2AMEN1MAPTL3MBTL1ALDH1A1 | |
| SCHEMBL1405267 | 0.85 | KMT2A (0.58) | KMT2AMEN1MAPTL3MBTL1ALDH1A1 | |
| SCHEMBL1405268 | 0.85 | KMT2A (0.58) | KMT2AMEN1MAPTL3MBTL1ALDH1A1 | |
| Fluoride SCHEMBL28089840 | 0.83 | KMT2A (0.57) | KMT2AMEN1MAPTL3MBTL1ALDH1A1 | |
| SCHEMBL1405475 | 0.82 | CA1 (0.60) | KMT2AMEN1MAPTL3MBTL1ALDH1A1 | |
| SCHEMBL1405477 | 0.82 | CA1 (0.60) | KMT2AMEN1MAPTL3MBTL1ALDH1A1 | |
| SCHEMBL11330630 | 0.82 | KMT2A (0.56) | KMT2AMEN1MAPTL3MBTL1ALDH1A1 | |
| SCHEMBL11145990 | 0.82 | KMT2A (0.56) | KMT2AMEN1MAPTL3MBTL1ALDH1A1 | |
| SCHEMBL29926116 | 0.82 | KMT2A (0.56) | KMT2AMEN1MAPTL3MBTL1ALDH1A1 | |
| SCHEMBL10568642 | 0.82 | KMT2A (0.65) | KMT2AMEN1MAPTL3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1144385-A1 | BENZOHETEROCYCLES AND THEIR USE AS MEK INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2001-10-17 | — | — | EP | disclosed |
| WO-2000042022-A1 | BENZOHETEROCYCLES AND THEIR USE AS MEK INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2000-07-20 | — | — | WO | disclosed |