Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 19/20 | 0.68 |
| ▸ | HTR2C | P28335 | 18/20 | 0.68 |
| ▸ | KCNH2 | Q12809 | 17/20 | 0.68 |
| ▸ | DRD2 | P14416 | 9/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5210193 | 0.82 | HTR2A (1.00) | HTR2AHTR2CKCNH2DRD2 | |
| SCHEMBL6585510 | 0.81 | HTR2A (0.83) | HTR2AHTR2CKCNH2DRD2 | |
| SCHEMBL6589393 | 0.79 | HTR2A (0.87) | HTR2AHTR2CKCNH2DRD2 | |
| SCHEMBL6588137 | 0.78 | HTR2A (1.00) | HTR2AHTR2CKCNH2DRD2 | |
| SCHEMBL6586256 | 0.78 | HTR2A (0.70) | HTR2AHTR2CKCNH2DRD2 | |
| SCHEMBL6586485 | 0.76 | HTR2A (1.00) | HTR2AHTR2CKCNH2DRD2 | |
| SCHEMBL6587947 | 0.75 | HTR2A (0.76) | HTR2AHTR2CKCNH2DRD2 | |
| SCHEMBL7812233 | 0.75 | HTR2A (0.71) | HTR2AHTR2CKCNH2DRD2 | |
| SCHEMBL6583933 | 0.75 | HTR2A (0.71) | HTR2AHTR2CKCNH2DRD2 | |
| SCHEMBL6586878 | 0.75 | HTR2A (0.74) | HTR2AHTR2CKCNH2DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1147084-A1 | PHENYLSULPHONYL DERIVATIVES AS 5-HT RECEPTOR LIGANDS | MERCK SHARP & DOHME LTD. (GB) | 2001-10-24 | — | — | EP | claimed |
| WO-2000043362-A1 | PHENYLSULPHONYL DERIVATIVES AS 5-HT RECEPTOR LIGANDS | MERCK SHARP & DOHME LIMITED (GB) | 2000-07-27 | — | — | WO | claimed |
| EP-1147084-A1 | PHENYLSULPHONYL DERIVATIVES AS 5-HT RECEPTOR LIGANDS | MERCK SHARP & DOHME LTD. (GB) | 2001-10-24 | — | — | EP | disclosed |
| WO-2000043362-A1 | PHENYLSULPHONYL DERIVATIVES AS 5-HT RECEPTOR LIGANDS | MERCK SHARP & DOHME LIMITED (GB) | 2000-07-27 | — | — | WO | disclosed |