Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 1/20 | 0.48 |
| ▸ | PDE10A | Q9Y233 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | CYSLTR1 | Q9Y271 | 9/20 | 0.40 |
| ▸ | CYSLTR2 | Q9NS75 | 8/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2567212 | 0.86 | BACE1 (0.53) | CCR1PDE10AKDM4ECYSLTR1CYSLTR2 | |
| SCHEMBL14911387 | 0.85 | PDE10A (0.46) | PDE10AKDM4ECYSLTR1CYSLTR2HDAC1 | |
| SCHEMBL17179265 | 0.80 | PDE10A (0.45) | PDE10AKDM4ECYSLTR1CYSLTR2BACE1 | |
| SCHEMBL5208223 | 0.80 | PDE10A (0.42) | PDE10AKDM4ECYSLTR1CYSLTR2HDAC1 | |
| SCHEMBL1193428 | 0.80 | CCR1 (0.48) | CCR1PDE10AKDM4ECYSLTR1CYSLTR2 | |
| SCHEMBL27561346 | 0.78 | CYSLTR2 (0.48) | PDE10AKDM4ECYSLTR1CYSLTR2HDAC1 | |
| SCHEMBL14352666 | 0.77 | IDO1 (0.46) | PDE10ACYSLTR1CYSLTR2BACE1KMT2A | |
| SCHEMBL12517340 | 0.76 | CCR1 (0.48) | CCR1PDE10AKDM4ECYSLTR1KMT2A | |
| SCHEMBL2672475 | 0.76 | CCR1 (0.48) | CCR1PDE10AKDM4ECYSLTR1CYSLTR2 | |
| SCHEMBL7809623 | 0.76 | S1PR4 (0.49) | CCR1PDE10AHDAC1HDAC2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0685478-B1 | QUINOLINE DERIVATIVES | UBE INDUSTRIES (JP) | 2001-10-24 | — | — | EP | disclosed |
| CN-1046279-C | Quinoline derivative | UBE INDUSTRIES (JP) | 1999-11-10 | — | — | CN | disclosed |
| US-5591752-A | LEUKOTRIENE ANTAGONIST, ANTIALLERGEN, ANTIINFLAMMATORY AGENT, DIBENZ(B,E)OXEPINE | UBE INDUSTRIES, LTD. (JP) | 1997-01-07 | — | — | US | disclosed |
| EP-0685478-A1 | QUINOLINE DERIVATIVE | UBE INDUSTRIES, LTD. (JP) | 1995-12-06 | — | — | EP | disclosed |