Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR1 | Q9Y271 | 9/20 | 0.64 |
| ▸ | CYSLTR2 | Q9NS75 | 4/20 | 0.64 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.63 |
| ▸ | GPBAR1 | Q8TDU6 | 7/20 | 0.57 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.52 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10607508 | 0.92 | CYSLTR1 (0.71) | CYSLTR1CYSLTR2PDE10AGPBAR1FFAR1 | |
| SCHEMBL10545699 | 0.89 | CYSLTR1 (0.68) | CYSLTR1CYSLTR2PDE10AGPBAR1 | |
| SCHEMBL9031944 | 0.87 | CYSLTR1 (0.66) | CYSLTR1CYSLTR2PDE10AGPBAR1FFAR1 | |
| SCHEMBL9031363 | 0.87 | CYSLTR1 (0.66) | CYSLTR1CYSLTR2PDE10AGPBAR1FFAR1 | |
| SCHEMBL10512475 | 0.85 | PDE10A (0.77) | CYSLTR1CYSLTR2PDE10AGPBAR1CYP1A2 | |
| SCHEMBL9828564 | 0.85 | CYSLTR1 (0.65) | CYSLTR1CYSLTR2PDE10AGPBAR1FFAR1 | |
| SCHEMBL7007566 | 0.85 | CYSLTR1 (0.62) | CYSLTR1CYSLTR2GPBAR1 | |
| SCHEMBL7005048 | 0.84 | CYSLTR1 (0.66) | CYSLTR1CYSLTR2GPBAR1 | |
| SCHEMBL1423457 | 0.83 | CYSLTR1 (0.62) | CYSLTR1CYSLTR2PDE10AGPBAR1 | |
| SCHEMBL9828521 | 0.83 | CYSLTR1 (0.58) | CYSLTR1CYSLTR2PDE10AGPBAR1FFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0775133-B1 | NAPHTHALENE AMIDES HAVING LEUKOTRIENE-ANTAGONISTIC ACTION | MENARINI LAB (ES) | 2001-05-30 | — | — | EP | disclosed |
| EP-0775133-A1 | NAPHTHALENE AMIDES HAVING LEUKOTRIENE-ANTAGONISTIC ACTION | LABORATORIOS MENARINI S.A. (ES) | 1997-05-28 | — | — | EP | disclosed |
| WO-1996004267-A1 | NAPHTHALENE AMIDES HAVING LEUKOTRIENE-ANTAGONISTIC ACTION | LABORATORIOS MENARINI S.A. (ES) | 1996-02-15 | — | — | WO | disclosed |