Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 15/20 | 0.47 |
| ▸ | PRSS1 | P07477 | 10/20 | 0.47 |
| ▸ | PRSS2 | P07478 | 3/20 | 0.37 |
| ▸ | PRSS3 | P35030 | 3/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7824393 | 0.87 | MAPT (0.46) | F2HTTKDM4EPOLBMAPT | |
| SCHEMBL7505080 | 0.87 | F2 (0.61) | F2PRSS1PRSS2PRSS3 | |
| SCHEMBL7817991 | 0.82 | F2 (0.52) | F2PRSS1PRSS2PRSS3 | |
| SCHEMBL7817035 | 0.81 | F2 (0.47) | F2PRSS1HTTKDM4EPOLB | |
| SCHEMBL7817688 | 0.79 | F2 (0.43) | F2PRSS1PRSS2PRSS3 | |
| SCHEMBL7817160 | 0.78 | F2 (0.41) | F2PRSS1PRSS2PRSS3 | |
| SCHEMBL7824021 | 0.77 | F2 (0.39) | F2PRSS1PRSS2PRSS3 | |
| Hydrochloric Acid SCHEMBL8185114 | 0.77 | F2 (0.42) | F2PRSS1PRSS2PRSS3 | |
| SCHEMBL7818083 | 0.76 | F2 (0.41) | F2PRSS1PRSS2PRSS3 | |
| SCHEMBL7819771 | 0.76 | F2 (0.41) | F2PRSS1PRSS2PRSS3KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0900207-B1 | PYRAZINONE THROMBIN INHIBITORS | MERCK & CO INC (US) | 2001-11-21 | — | — | EP | disclosed |