Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.49 |
| ▸ | BCL3 | P20749 | 4/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.46 |
| ▸ | LCK | P06239 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 3/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | CASR | P41180 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6477549 | 0.91 | MAPK14 (0.55) | BCL3POLBKMT2AMAPTALDH1A1 | |
| SCHEMBL7809423 | 0.81 | EPHX2 (0.62) | EPHX2MAPTALDH1A1KDM4EMAPK14 | |
| SCHEMBL6487023 | 0.80 | MAPK14 (0.61) | KMT2AMAPTALDH1A1KDM4EMAPK14 | |
| SCHEMBL8158266 | 0.75 | HSD17B10 (0.58) | POLBKMT2AMAPTALDH1A1KDM4E | |
| SCHEMBL6476913 | 0.73 | MAPK14 (0.71) | EPHX2MAPTALDH1A1KDM4EMAPK14 | |
| SCHEMBL4524250 | 0.69 | KDM4E (0.63) | BCL3POLBKMT2AALDH1A1KDM4E | |
| SCHEMBL25976323 | 0.69 | SMN1; SMN2 (0.73) | POLBKMT2AMAPTALDH1A1HTT | |
| SCHEMBL10846258 | 0.67 | POLB (0.64) | BCL3POLBKMT2AMAPTALDH1A1 | |
| SCHEMBL29849750 | 0.67 | BCL3 (0.76) | BCL3POLBKMT2AMAPTALDH1A1 | |
| SCHEMBL16431474 | 0.67 | BCL3 (0.76) | BCL3POLBKMT2AMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1077931-A1 | BENZAMIDE DERIVATIVES FOR THE TREATMENT OF DISEASES MEDIATED BY CYTOKINES | AstraZeneca AB (SE) | 2001-02-28 | — | — | EP | disclosed |
| WO-1999059959-A1 | BENZAMIDE DERIVATIVES FOR THE TREATMENT OF DISEASES MEDIATED BY CYTOKINES | ASTRAZENECA AB (SE) | 1999-11-25 | — | — | WO | disclosed |