Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 7/20 | 0.46 |
| ▸ | ECE1 | P42892 | 1/20 | 0.43 |
| ▸ | MUS81 | Q96NY9 | 1/20 | 0.43 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | APP | P05067 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | SNCA | P37840 | 1/20 | 0.36 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7810404 | 0.96 | TOP2A (0.46) | TOP2AECE1MUS81KDM4CTDP1 | |
| SCHEMBL7811837 | 0.96 | ECE1 (0.48) | TOP2AECE1MUS81KDM4CTDP1 | |
| SCHEMBL7804823 | 0.93 | TOP2A (0.44) | TOP2AECE1MUS81KDM4CTDP1 | |
| SCHEMBL7810430 | 0.92 | TOP2A (0.45) | TOP2AECE1MUS81KDM4CTDP1 | |
| SCHEMBL7810464 | 0.91 | TOP2A (0.42) | TOP2AECE1MUS81KDM4CTDP1 | |
| SCHEMBL7810277 | 0.91 | TOP2A (0.42) | TOP2AECE1MUS81TDP1 | |
| SCHEMBL7811716 | 0.91 | TOP2A (0.59) | TOP2AECE1MUS81KDM4CTDP1 | |
| SCHEMBL7804649 | 0.90 | TOP2A (0.60) | TOP2AECE1MUS81KDM4CTDP1 | |
| SCHEMBL7814297 | 0.90 | ECE1 (0.49) | TOP2AECE1MUS81KDM4CTDP1 | |
| Hydrochloric Acid SCHEMBL7823890 | 0.89 | ECE1 (0.48) | TOP2AECE1MUS81KDM4CTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0662076-B1 | 2-AMINOALKYL-5-AMINOALKYLAMINO SUBSTITUTED ISOQUINOINDAZOLE-6-(2H)-ONES WITH ANTITUMOUR ACTIVITY | UNIV VERMONT (US) | 2001-04-11 | — | — | EP | claimed |
| US-5604246-A | HAVING POTENCY AGAINST MULTIDRUG RESISTANT TUMORS | BOEHRINGER MANNHEIM ITALIA SPA (IT) | 1997-02-18 | — | — | US | disclosed |