SCHEMBL7810258

SCHEMBL7810258

FC(F)(F)CCCOc1nsnc1OC1CN2CCC1C2

nearest known ligand 0.64

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CHRM1 P11229 12/20 0.64
CHRM2 P08172 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7810254 0.85 CHRM1 (0.57) CHRM1CHRM2
SCHEMBL6785589 0.83 CHRM1 (0.71) CHRM1CHRM2
SCHEMBL7819633 0.83 CHRM1 (0.62) CHRM1CHRM2
SCHEMBL6781184 0.81 CHRM1 (0.66) CHRM1CHRM2
SCHEMBL6781848 0.81 CHRM1 (0.73) CHRM1
SCHEMBL8068625 0.79 CHRM1 (0.53) CHRM1CHRM2
SCHEMBL6786491 0.79 CHRM1 (0.64) CHRM1CHRM2
SCHEMBL7817611 0.78 CHRM1 (0.52) CHRM1CHRM2
SCHEMBL6784896 0.77 CHRM1 (0.53) CHRM1CHRM2
SCHEMBL6790328 0.77 CHRM1 (0.55) CHRM1CHRM2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6069159-A USEFUL AS STIMULANTS OF THE COGNITIVE FUNCTION OF THE FOREBRAIN AND HIPPOCAMPUS OF MAMMALS ELI LILLY AND COMPANY (US) 2000-05-30 US claimed
EP-0900217-A4 HETEROCYCLIC COMPOUNDS LILLY CO ELI (US) 2001-05-23 EP disclosed
US-6069159-A USEFUL AS STIMULANTS OF THE COGNITIVE FUNCTION OF THE FOREBRAIN AND HIPPOCAMPUS OF MAMMALS ELI LILLY AND COMPANY (US) 2000-05-30 US disclosed
EP-0900217-A1 HETEROCYCLIC COMPOUNDS ELI LILLY AND COMPANY (US) 1999-03-10 EP disclosed
WO-1997040042-A1 HETEROCYCLIC COMPOUNDS ELI LILLY AND COMPANY (US) 1997-10-30 WO disclosed