Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 20/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 19/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 12/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7811639 | 0.82 | SLC6A4 (0.61) | SLC6A4SLC6A3SLC6A2CYP2D6 | |
| SCHEMBL6543319 | 0.79 | SLC6A4 (0.45) | SLC6A4SLC6A3SLC6A2CYP2D6 | |
| SCHEMBL5901153 | 0.78 | SLC6A4 (0.43) | SLC6A4SLC6A3SLC6A2CYP2D6 | |
| SCHEMBL27528569 | 0.78 | SLC6A4 (0.43) | SLC6A4SLC6A3SLC6A2CYP2D6 | |
| SCHEMBL7371366 | 0.77 | SLC6A4 (0.63) | SLC6A4SLC6A3SLC6A2CYP2D6 | |
| SCHEMBL5086634 | 0.76 | SLC6A4 (0.64) | SLC6A4SLC6A3SLC6A2 | |
| SCHEMBL6543222 | 0.75 | SLC6A4 (0.46) | SLC6A4SLC6A3SLC6A2CYP2D6 | |
| SCHEMBL7811794 | 0.75 | SLC6A4 (0.44) | SLC6A4SLC6A3SLC6A2CYP2D6 | |
| SCHEMBL6999461 | 0.73 | SLC6A4 (0.41) | SLC6A4SLC6A3SLC6A2CYP2D6 | |
| SCHEMBL6956287 | 0.72 | TACR1 (0.45) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0775132-B1 | (AZETIDIN-1-YLALKYL)LACTAMS AS TACHYKININ ANTAGONISTS | PFIZER LTD (GB) | 2001-03-28 | — | — | EP | disclosed |
| US-5968923-A | ANTIINFLAMMATORY AGENTS, TREATMENT OF NERVOUS SYSTEM DISORDERS, GASTROINTESTINAL DISORDERS | PFIZER INC. (US) | 1999-10-19 | — | — | US | disclosed |
| WO-1996005193-A1 | (AZETIDIN-1-YLALKYL)LACTAMS AS TACHYKININ ANTAGONISTS | PFIZER LIMITED (GB) | 1996-02-22 | — | — | WO | disclosed |