Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 1/20 | 0.45 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.45 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.43 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.42 |
| ▸ | PREP | P48147 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31209794 | 0.92 | HPGD (0.46) | CHRM2CHRM1CHRM3HPGDMEN1 | |
| SCHEMBL31208822 | 0.92 | HPGD (0.46) | CHRM2CHRM1CHRM3HPGDMEN1 | |
| SCHEMBL2673520 | 0.91 | CHRM2 (0.47) | CHRM2CHRM1CHRM3HPGDMEN1 | |
| SCHEMBL2673522 | 0.91 | CHRM2 (0.47) | CHRM2CHRM1CHRM3HPGDMEN1 | |
| SCHEMBL2674263 | 0.91 | CHRM2 (0.47) | CHRM2CHRM1CHRM3HPGDMEN1 | |
| SCHEMBL2673809 | 0.84 | NR1H2 (0.49) | CHRM2CHRM1CHRM3HPGDMEN1 | |
| SCHEMBL24359058 | 0.84 | NR1H2 (0.49) | CHRM2CHRM1CHRM3HPGDMEN1 | |
| SCHEMBL15664395 | 0.84 | HPGD (0.51) | CHRM2CHRM1CHRM3HPGDMEN1 | |
| SCHEMBL22737529 | 0.84 | HPGD (0.43) | CHRM2CHRM1CHRM3HPGDMEN1 | |
| SCHEMBL22737632 | 0.84 | HPGD (0.43) | CHRM2CHRM1CHRM3HPGDMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0775132-B1 | (AZETIDIN-1-YLALKYL)LACTAMS AS TACHYKININ ANTAGONISTS | PFIZER LTD (GB) | 2001-03-28 | — | — | EP | disclosed |
| US-5968923-A | ANTIINFLAMMATORY AGENTS, TREATMENT OF NERVOUS SYSTEM DISORDERS, GASTROINTESTINAL DISORDERS | PFIZER INC. (US) | 1999-10-19 | — | — | US | disclosed |
| WO-1996005193-A1 | (AZETIDIN-1-YLALKYL)LACTAMS AS TACHYKININ ANTAGONISTS | PFIZER LIMITED (GB) | 1996-02-22 | — | — | WO | disclosed |