Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.77 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.77 |
| ▸ | GRIA1 | P42261 | 2/20 | 0.70 |
| ▸ | GRIA2 | P42262 | 2/20 | 0.70 |
| ▸ | GRIA3 | P42263 | 2/20 | 0.70 |
| ▸ | GRIA4 | P48058 | 2/20 | 0.70 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.65 |
| ▸ | GRIK2 | Q13002 | 2/20 | 0.65 |
| ▸ | GRIK3 | Q13003 | 2/20 | 0.65 |
| ▸ | GRIK4 | Q16099 | 2/20 | 0.65 |
| ▸ | GRIK5 | Q16478 | 2/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8191257 | 0.96 | SLC22A6 (0.71) | SLC22A6SLC22A8GRIA1GRIA2GRIA3 | |
| SCHEMBL30661067 | 0.90 | GRIK1 (0.71) | SLC22A6SLC22A8GRIA1GRIA2GRIA3 | |
| SCHEMBL26665189 | 0.90 | GRIK1 (0.71) | SLC22A6SLC22A8GRIA1GRIA2GRIA3 | |
| SCHEMBL8181056 | 0.89 | GRIK1 (0.70) | SLC22A6SLC22A8GRIA1GRIA2GRIA3 | |
| SCHEMBL8610087 | 0.88 | GRIK1 (0.82) | SLC22A6SLC22A8GRIA1GRIA2GRIA3 | |
| Zonampanel SCHEMBL29379917 | 0.87 | SLC22A6 (1.00) | SLC22A6SLC22A8GRIA1GRIA2GRIA3 | |
| Zonampanel SCHEMBL678832 | 0.87 | SLC22A6 (1.00) | SLC22A6SLC22A8GRIA1GRIA2GRIA3 | |
| SCHEMBL8191168 | 0.87 | SLC22A6 (0.56) | SLC22A6SLC22A8GRIA1GRIA2GRIA3 | |
| Zonampanel SCHEMBL3045139 | 0.86 | SLC22A6 (0.98) | SLC22A6SLC22A8GRIA1GRIA2GRIA3 | |
| SCHEMBL7814578 | 0.86 | SLC22A6 (0.84) | SLC22A6SLC22A8GRIA1GRIA2GRIA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0784054-B1 | 1,2,3,4-TETRAHYDROQUINOXALINEDIONE DERIVATIVES AND USE AS GLUTAMATE RECEPTOR ANTAGONISTS | YAMANOUCHI PHARMA CO LTD (JP) | 2001-11-28 | — | — | EP | disclosed |
| CN-1067387-C | 1,2,3,4-tetrahydroquinoxalindione derivative | YAMANOUCHI PHARMA CO LTD (JP) | 2001-06-20 | — | — | CN | disclosed |
| US-6096743-A | 1,2,3,4-tetrahydroquinoxalinedione derivative | YAMANOUCHI PHARMACEUTICALS CO., LTD. (JP) | 2000-08-01 | — | — | US | disclosed |
| CN-1168670-A | 1,2,3,4-tetrahydroquinoxalindione derivative | YAMANOUCHI PHARMA CO LTD (JP) | 1997-12-24 | — | — | CN | disclosed |
| EP-0784054-A1 | 1,2,3,4-TETRAHYDROQUINOXALINEDIONE DERIVATIVE | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1997-07-16 | — | — | EP | disclosed |