Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Ethylenediamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK2A1 | P68400 | 3/20 | 0.71 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.59 |
| ▸ | MTOR | P42345 | 3/20 | 0.58 |
| ▸ | SMG1 | Q96Q15 | 3/20 | 0.58 |
| ▸ | CLK1 | P49759 | 1/20 | 0.56 |
| ▸ | CLK2 | P49760 | 1/20 | 0.56 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.56 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.56 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.56 |
| ▸ | AURKA | O14965 | 7/20 | 0.56 |
| ▸ | CDK1 | P06493 | 2/20 | 0.56 |
| ▸ | CDK2 | P24941 | 2/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | CDK4 | P11802 | 1/20 | 0.56 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.56 |
| ▸ | XBP1 | P17861 | 1/20 | 0.56 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.56 |
| ▸ | CCND1 | P24385 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4897306 | 0.99 | CSNK2A1 (0.73) | CSNK2A1CAMK2DMTORSMG1CLK1 | |
| SCHEMBL4897031 | 0.89 | MTOR (0.64) | CSNK2A1CAMK2DMTORSMG1CLK1 | |
| SCHEMBL4900780 | 0.87 | CDK1 (0.74) | CSNK2A1MTORSMG1CLK1CLK2 | |
| SCHEMBL6110038 | 0.87 | AURKA (0.60) | CSNK2A1MTORSMG1CLK1CLK2 | |
| SCHEMBL4905384 | 0.85 | CDK1 (0.71) | CSNK2A1CAMK2DMTORSMG1CLK1 | |
| SCHEMBL6107154 | 0.85 | MTOR (0.55) | CSNK2A1MTORSMG1CLK1CLK2 | |
| SCHEMBL7813904 | 0.85 | CSNK2A1 (0.55) | CSNK2A1MTORSMG1CLK1CLK2 | |
| SCHEMBL6109957 | 0.84 | MTOR (0.54) | CSNK2A1MTORSMG1CLK1CLK2 | |
| SCHEMBL7813711 | 0.84 | CSNK2A1 (0.57) | CSNK2A1MTORSMG1CLK1CLK2 | |
| SCHEMBL6107651 | 0.83 | CSNK2A1 (1.00) | CSNK2A1CAMK2DMTORSMG1CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0672041-B1 | PHARMACOLOGICALLY ACTIVE PYRIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF | NOVARTIS AG (CH) | 2001-11-14 | — | — | EP | disclosed |