Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FNTA | P49354 | 1/20 | 0.37 |
| ▸ | FNTB | P49356 | 1/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 3/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.31 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | CNR1 | P21554 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8304606 | 0.80 | FNTA (0.40) | FNTAFNTBCYP19A1NPC1TP53 | |
| Hydrochloric Acid SCHEMBL8387447 | 0.79 | FNTA (0.39) | FNTAFNTBCYP19A1NPC1TP53 | |
| SCHEMBL8619070 | 0.76 | HRH3 (0.44) | CYP19A1NPC1TP53RAB9AKMT2A | |
| Hydrochloric Acid SCHEMBL8690838 | 0.75 | HRH3 (0.43) | CYP19A1NPC1TP53RAB9AKMT2A | |
| SCHEMBL8620754 | 0.73 | CYP19A1 (0.38) | FNTAFNTBCYP19A1CNR2CNR1 | |
| SCHEMBL8626473 | 0.73 | FNTA (0.47) | FNTAFNTB | |
| SCHEMBL8505582 | 0.70 | NPC1 (0.39) | FNTAFNTBCYP19A1NPC1TP53 | |
| Hydrochloric Acid SCHEMBL8504372 | 0.70 | NPC1 (0.39) | FNTAFNTBCYP19A1NPC1TP53 | |
| SCHEMBL8392034 | 0.69 | CYP19A1 (0.38) | FNTAFNTBCYP19A1TP53SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL8133317 | 0.69 | KMT2A (0.47) | FNTAFNTBNPC1TP53RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0891353-A4 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2001-08-08 | — | — | EP | disclosed |
| EP-0891353-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 1999-01-20 | — | — | EP | disclosed |
| US-5780492-A | ANTICARCINOGENIC AGENTS | MERCK & CO., INC. (US) | 1998-07-14 | — | — | US | disclosed |
| WO-1997036892-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1997-10-09 | — | — | WO | disclosed |