Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 14/20 | 0.59 |
| ▸ | HTR1B | P28222 | 13/20 | 0.59 |
| ▸ | HTR1A | P08908 | 4/20 | 0.59 |
| ▸ | HTR1F | P30939 | 3/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | BLM | P54132 | 1/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.58 |
| ▸ | THPO | P40225 | 1/20 | 0.58 |
| ▸ | APP | P05067 | 1/20 | 0.53 |
| ▸ | NOS1 | P29475 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7811478 | 1.00 | HTR1D (0.59) | HTR1DHTR1BHTR1AHTR1FMAPT | |
| SCHEMBL7811697 | 0.85 | HTR1D (0.60) | HTR1DHTR1BHTR1AHTR1FMAPT | |
| SCHEMBL252678 | 0.83 | HTR1D (0.62) | HTR1DHTR1BHTR1AHTR1FMAPT | |
| SCHEMBL9764751 | 0.82 | HTR1D (0.65) | HTR1DHTR1BHTR1AHTR1FMAPT | |
| SCHEMBL9764535 | 0.81 | HTR1D (0.64) | HTR1DHTR1BHTR1AHTR1FMAPT | |
| Naratriptan SCHEMBL8843887 | 0.80 | HTR1D (0.77) | HTR1DHTR1BHTR1AHTR1FMAPT | |
| SCHEMBL9035197 | 0.79 | CYP1A2 (0.61) | HTR1DHTR1BHTR1AHTR1FMAPT | |
| SCHEMBL8786074 | 0.78 | HTR1D (0.63) | HTR1DHTR1BHTR1AHTR1FMAPT | |
| SCHEMBL8417739 | 0.77 | HTR1D (0.69) | HTR1DHTR1BHTR1AHTR1FMAPT | |
| SCHEMBL8417741 | 0.77 | HTR1D (0.69) | HTR1DHTR1BHTR1AHTR1FMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0636623-B1 | Indole derivatives as 5-HT1- like agonists | ASTRAZENECA AB (SE) | 2001-08-16 | — | — | EP | disclosed |
| EP-0486666-B1 | THERAPEUTIC HETEROCYCLIC COMPOUNDS | ZENECA LTD (GB) | 1997-08-13 | — | — | EP | disclosed |
| US-5466699-A | Indolyl compounds for treating migraine | BURROUGHS WELLCOME CO. (US) | 1995-11-14 | — | — | US | disclosed |
| US-5399574-A | 5-hydroxytryptamine agonists; vasoconstrictors | BURROUGHS WELLCOME CO. (US) | 1995-03-21 | — | — | US | disclosed |
| EP-0636623-A1 | Indole derivatives as 5-HT1- like agonists | THE WELLCOME FOUNDATION LIMITED (GB) | 1995-02-01 | — | — | EP | disclosed |