Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 5/20 | 0.47 |
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.39 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.39 |
| ▸ | CYP2A6 | P11509 | 3/20 | 0.38 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.38 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.38 |
| ▸ | MGLL | Q99685 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7716348 | 0.87 | SLC6A4 (0.43) | SLC6A4DRD2SLC6A3SLC6A2ALOX5 | |
| SCHEMBL28359596 | 0.79 | SLC6A4 (0.61) | SLC6A4DRD2SLC6A3SLC6A2ALOX5 | |
| SCHEMBL31172103 | 0.79 | SLC6A4 (0.61) | SLC6A4DRD2SLC6A3SLC6A2ALOX5 | |
| SCHEMBL4670974 | 0.79 | SLC6A4 (0.54) | SLC6A4DRD2SLC6A3SLC6A2ALOX5 | |
| SCHEMBL6752313 | 0.78 | SLC6A4 (0.38) | SLC6A4DRD2SLC6A3SLC6A2ALOX5 | |
| SCHEMBL5744613 | 0.78 | SLC6A4 (0.38) | SLC6A4DRD2SLC6A3SLC6A2ALOX5 | |
| SCHEMBL20172556 | 0.72 | SLC6A4 (0.39) | SLC6A4DRD2SLC6A3SLC6A2ALOX5 | |
| SCHEMBL29261831 | 0.72 | SLC6A4 (0.46) | SLC6A4DRD2SLC6A3SLC6A2ALOX5 | |
| SCHEMBL2708963 | 0.71 | SLC6A4 (0.54) | SLC6A4DRD2SLC6A3SLC6A2ALOX5 | |
| SCHEMBL14559225 | 0.70 | SLC6A4 (0.38) | SLC6A4DRD2SLC6A3SLC6A2ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0873340-B1 | HETEROCYCLIC SUBSTITUTED CYCLOPENTANE COMPOUNDS | ABBOTT LAB (US) | 2001-11-21 | — | — | EP | disclosed |
| US-6143749-A | Heterocyclic substituted cyclopentane compounds | ABBOTT LABORATORIES (US) | 2000-11-07 | — | — | US | disclosed |
| US-5665721-A | ADENOSINE KINASE INHIBITORS | ABBOTT LABORATORIES (US) | 1997-09-09 | — | — | US | disclosed |