SCHEMBL7811986

SCHEMBL7811986

COc1ccc2c(c1)C(C)(C)c1[nH]c3c(F)c(N)ccc3c1C2=O

nearest known ligand 0.68

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
ALK Q9UM73 20/20 0.68

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20004158 0.90 ALK (0.63) ALK
SCHEMBL7808412 0.90 ALK (0.78) ALK
SCHEMBL897757 0.88 ALK (0.61) ALK
SCHEMBL1755984 0.87 ALK (0.68) ALK
SCHEMBL7804733 0.87 ALK (0.68) ALK
SCHEMBL898145 0.85 ALK (0.78) ALK
SCHEMBL7812139 0.83 ALK (0.70) ALK
SCHEMBL7811472 0.81 ALK (0.56) ALK
SCHEMBL897461 0.81 ALK (1.00) ALK
SCHEMBL897884 0.80 ALK (0.56) ALK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2010143664-A1 TETRACYCLIC COMPOUND 中外製薬株式会社 (JP) 2010-12-16 WO disclosed