Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | PRPS1 | P60891 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7815243 | 0.77 | PRMT5 (0.47) | PRPS1 | |
| SCHEMBL7810839 | 0.71 | NOTUM (0.33) | — | |
| SCHEMBL10775917 | 0.67 | DPP4 (0.48) | SIRT2HTR2AHTR2C | |
| SCHEMBL5982758 | 0.65 | PTPN1 (0.40) | — | |
| SCHEMBL7837380 | 0.65 | CYP11B1 (0.31) | — | |
| SCHEMBL11097315 | 0.63 | SIRT2 (0.31) | SIRT2 | |
| SCHEMBL2157981 | 0.63 | CYP11B1 (0.39) | — | |
| SCHEMBL10780482 | 0.59 | CYP1A2 (0.40) | HTR2AHTR2C | |
| SCHEMBL7834874 | 0.58 | PTGER4 (0.33) | PRPS1 | |
| SCHEMBL29368277 | 0.56 | CYP3A4 (0.62) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0745600-B1 | Benzimidazole derivatives, their preparation and their therapeutic use | SANKYO CO (JP) | 2001-10-24 | — | — | EP | disclosed |
| US-5886014-A | TREATMENT AND/OR PROPHYLAXIS OF A VARIETY OF DISORDERS, INCLUDING HYPERLIPEMIA, HYPERGLYCEMIA, OBESITY, IMPAIRED GLUCOSE TOLERANCE (IGT), INSULIN RESISTANCE AND DIABETIC COMPLICATIONS | SANKYO COMPANY, LIMITED (JP) | 1999-03-23 | — | — | US | disclosed |
| EP-0745600-A1 | Benzimidazole derivatives, their preparation and their therapeutic use | SANKYO COMPANY LIMITED (JP) | 1996-12-04 | — | — | EP | disclosed |