SCHEMBL7813331

SCHEMBL7813331

O=C(Nc1ccccc1)N1CCN(C(=O)O)C(CN2CCC(Cc3ccc(F)cc3)CC2)C1

nearest known ligand 0.64

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CCR3 P51677 16/20 0.64
FAAH O00519 2/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7821828 0.89 CCR3 (0.81) CCR3
SCHEMBL5352517 0.88 CCR3 (0.83) CCR3FAAH
SCHEMBL7825001 0.87 CCR3 (0.76) CCR3FAAH
SCHEMBL7814197 0.84 CCR3 (0.77) CCR3FAAH
SCHEMBL5352505 0.83 CCR3 (0.67) CCR3
SCHEMBL7829373 0.82 CCR3 (0.77) CCR3FAAH
SCHEMBL7820927 0.82 CCR3 (0.70) CCR3FAAH
SCHEMBL7814172 0.82 CCR3 (0.78) CCR3FAAH
SCHEMBL5351562 0.82 CCR3 (0.78) CCR3FAAH
SCHEMBL7824738 0.81 CCR3 (0.60) CCR3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1140834-A1 HETEROCYCLIC PIPERIDINES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY Du Pont Pharmaceuticals Company (US) 2001-10-10 EP disclosed
WO-2000035877-A1 HETEROCYCLIC PIPERIDINES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY DU PONT PHARMACEUTICALS COMPANY (US) 2000-06-22 WO disclosed