Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 12/20 | 0.45 |
| ▸ | KIT | P10721 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | STAT1 | P42224 | 1/20 | 0.32 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.32 |
| ▸ | RELA | Q04206 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL858889 | 0.91 | PIK3CA (0.36) | PIK3CAKITSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL856908 | 0.90 | PIK3CA (0.46) | PIK3CAKITALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL3806412 | 0.86 | PIK3CA (0.47) | PIK3CAKITALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL856219 | 0.86 | PIK3CA (0.46) | PIK3CAKITALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL856402 | 0.84 | PIK3CA (0.49) | PIK3CASMN1; SMN2KDM4EALDH1A1NPC1 | |
| SCHEMBL856858 | 0.82 | PIK3CA (0.43) | PIK3CASMN1; SMN2KDM4EALDH1A1NPC1 | |
| SCHEMBL856299 | 0.82 | PIK3CA (0.47) | PIK3CAKITSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL858155 | 0.81 | PIK3CA (0.37) | PIK3CAKITKDM4EALDH1A1HPGD | |
| SCHEMBL3755560 | 0.81 | PIK3CA (0.46) | PIK3CAKITALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL858974 | 0.81 | PIK3CA (0.46) | PIK3CAKITALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010135568-A1 | BENZOXAZEPINES AS INHIBITORS OF MTOR AND THEIR USE TO TREAT CANCER | EXELIXIS, INC. (US) | 2010-11-25 | — | — | WO | disclosed |