Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ZAP70 | P43403 | 2/20 | 0.79 |
| ▸ | PDGFRB | P09619 | 15/20 | 0.70 |
| ▸ | KDR | P35968 | 15/20 | 0.70 |
| ▸ | FGFR1 | P11362 | 14/20 | 0.70 |
| ▸ | EGFR | P00533 | 6/20 | 0.70 |
| ▸ | AKT2 | P31751 | 1/20 | 0.61 |
| ▸ | FLT1 | P17948 | 1/20 | 0.51 |
| ▸ | SRC | P12931 | 1/20 | 0.51 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.47 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7814700 | 1.00 | ZAP70 (0.79) | ZAP70PDGFRBKDRFGFR1EGFR | |
| SCHEMBL4407274 | 0.96 | ZAP70 (0.85) | ZAP70PDGFRBKDRFGFR1EGFR | |
| SCHEMBL4407278 | 0.96 | ZAP70 (0.85) | ZAP70PDGFRBKDRFGFR1EGFR | |
| SCHEMBL7814704 | 0.91 | ZAP70 (0.65) | ZAP70PDGFRBKDRFGFR1EGFR | |
| SCHEMBL4414158 | 0.88 | ZAP70 (1.00) | ZAP70PDGFRBKDRFGFR1EGFR | |
| SCHEMBL4414161 | 0.88 | ZAP70 (1.00) | ZAP70PDGFRBKDRFGFR1EGFR | |
| SCHEMBL4413149 | 0.85 | PDGFRB (0.77) | ZAP70PDGFRBKDRFGFR1EGFR | |
| SCHEMBL4413147 | 0.85 | PDGFRB (0.77) | ZAP70PDGFRBKDRFGFR1EGFR | |
| SCHEMBL4406627 | 0.84 | PDGFRB (0.75) | ZAP70PDGFRBKDRFGFR1EGFR | |
| SCHEMBL4406624 | 0.84 | PDGFRB (0.75) | ZAP70PDGFRBKDRFGFR1EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1082305-A4 | PYRROLE SUBSTITUTED 2-INDOLINONE PROTEIN KINASE INHIBITORS | SUGEN INC (US) | 2001-09-26 | — | — | EP | disclosed |
| EP-1082305-A1 | PYRROLE SUBSTITUTED 2-INDOLINONE PROTEIN KINASE INHIBITORS | Sugen, Inc. (US) | 2001-03-14 | — | — | EP | disclosed |
| WO-1999061422-A1 | PYRROLE SUBSTITUTED 2-INDOLINONE PROTEIN KINASE INHIBITORS | SUGEN, INC. (US) | 1999-12-02 | — | — | WO | disclosed |