Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 13/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | CASP7 | P55210 | 1/20 | 0.40 |
| ▸ | ECE1 | P42892 | 1/20 | 0.39 |
| ▸ | MUS81 | Q96NY9 | 1/20 | 0.39 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.35 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | TDP2 | O95551 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7804772 | 0.95 | TOP2A (0.57) | TOP2ASMN1; SMN2TP53CYP3A4MAPT | |
| SCHEMBL7817250 | 0.94 | TOP2A (0.44) | TOP2ASMN1; SMN2TP53MAPTBLM | |
| SCHEMBL7810513 | 0.93 | TOP2A (0.43) | TOP2AECE1MUS81TDP2TDP1 | |
| SCHEMBL7818986 | 0.93 | TOP2A (0.47) | TOP2ASMN1; SMN2TP53CYP3A4MAPT | |
| SCHEMBL7810397 | 0.91 | TOP2A (0.57) | TOP2ASMN1; SMN2TP53CYP3A4MAPT | |
| Topixantrone SCHEMBL29371930 | 0.91 | TOP2A (0.57) | TOP2ASMN1; SMN2TP53CYP3A4MAPT | |
| Topixantrone SCHEMBL1344518 | 0.91 | TOP2A (0.57) | TOP2ASMN1; SMN2TP53CYP3A4MAPT | |
| SCHEMBL7804602 | 0.91 | ECE1 (0.47) | TOP2AECE1MUS81TDP2TDP1 | |
| SCHEMBL7808820 | 0.91 | TOP2A (0.43) | TOP2AECE1MUS81TDP2TDP1 | |
| Topixantrone SCHEMBL1230381 | 0.90 | TOP2A (0.56) | TOP2ASMN1; SMN2TP53CYP3A4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0750619-B1 | HETERO-ANNULATED INDAZOLES | NOVUSPHARMA SPA (IT) | 2001-05-30 | — | — | EP | disclosed |
| US-5596097-A | ANTITUMOR AGENTS | THE UNIVERSITY OF VERMONT (US) | 1997-01-21 | — | — | US | disclosed |
| WO-1995024407-A1 | HETERO-ANNULATED INDAZOLES | BOEHRINGER MANNHEIM ITALIA, S.P.A. (IT) | 1995-09-14 | — | — | WO | disclosed |