Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 3/20 | 0.55 |
| ▸ | TDO2 | P48775 | 1/20 | 0.55 |
| ▸ | CDK4 | P11802 | 7/20 | 0.50 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | AHR | P35869 | 1/20 | 0.44 |
| ▸ | KMT5A | Q9NQR1 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | CCND1 | P24385 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9071199 | 0.93 | IDO1 (0.47) | IDO1TDO2CDK4PTGS1PTGS2 | |
| SCHEMBL16885422 | 0.87 | CDK4 (0.46) | IDO1TDO2CDK4PTGS1PTGS2 | |
| SCHEMBL13470368 | 0.80 | CDK4 (0.45) | CDK4PTGS1PTGS2KMT5AMEN1 | |
| SCHEMBL7818266 | 0.78 | IDO1 (0.55) | IDO1TDO2MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL1287137 | 0.78 | IDO1 (0.55) | IDO1TDO2MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL10719313 | 0.77 | IDO1 (0.51) | IDO1TDO2PTGS2MAPTRAB9A | |
| SCHEMBL10220599 | 0.77 | IDO1 (0.51) | IDO1TDO2MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL13470064 | 0.75 | CDK4 (0.45) | CDK4PTGS1PTGS2KMT5AMEN1 | |
| SCHEMBL12973032 | 0.75 | CDK4 (0.45) | CDK4PTGS1PTGS2KMT5AMEN1 | |
| SCHEMBL7808047 | 0.75 | IDO1 (0.79) | IDO1TDO2PTGS2ALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9725425-B1 | Compounds and methods for treating cancer | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2017-08-08 | — | — | US | disclosed |
| EP-0876356-B1 | USE OF TRICYCLIC 1,4-DIHYDRO-1,4-DIOXO-1H-NAPHTHALENE DERIVATIVES, RESULTING NOVEL COMPOUNDS AND THERAPEUTICAL USE THEREOF | INNOTHERA SA LAB (FR) | 2001-10-31 | — | — | EP | disclosed |
| US-6262095-B1 | TREATMENT OF ILLNESS ASSOCIATED WITH AN ALTERATION IN VENOUS FUNCTION AND/OR INFLAMMATORY EDEMA | LABORATOIRE INNOTHERA (FR) | 2001-07-17 | — | — | US | disclosed |