Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.60 |
| ▸ | HRH1 | P35367 | 2/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.45 |
| ▸ | HRH2 | P25021 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7814882 | 0.90 | TDP1 (0.55) | SMN1; SMN2CYP1A2CYP2C19HRH1TDP1 | |
| SCHEMBL16561480 | 0.84 | SMN1; SMN2 (0.60) | SMN1; SMN2CYP1A2CYP2C19HRH1HDAC1 | |
| SCHEMBL9774 | 0.83 | SMN1; SMN2 (0.68) | SMN1; SMN2CYP1A2CYP2C19HRH1TDP1 | |
| Hydrochloric Acid SCHEMBL3513717 | 0.81 | SMN1; SMN2 (0.66) | SMN1; SMN2CYP1A2CYP2C19HRH1TDP1 | |
| SCHEMBL6687222 | 0.80 | SMN1; SMN2 (0.73) | SMN1; SMN2CYP1A2CYP2C19HRH1HDAC1 | |
| SCHEMBL3673389 | 0.80 | SMN1; SMN2 (0.73) | SMN1; SMN2CYP1A2CYP2C19HRH1HDAC1 | |
| SCHEMBL6196923 | 0.80 | SMN1; SMN2 (0.68) | SMN1; SMN2CYP1A2CYP2C19HRH1TDP1 | |
| SCHEMBL966286 | 0.80 | CA1 (0.56) | SMN1; SMN2CYP1A2TDP1HPGDALOX15 | |
| SCHEMBL29672808 | 0.80 | CA1 (0.56) | SMN1; SMN2CYP1A2TDP1HPGDALOX15 | |
| SCHEMBL7379830 | 0.79 | SMN1; SMN2 (0.55) | SMN1; SMN2CYP1A2CYP2C19HRH1HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0694546-B1 | Substituted dibenzoxazepine compounds, pharmaceutical compositions and use | SEARLE & CO (US) | 2001-06-06 | — | — | EP | disclosed |
| EP-0694545-B1 | Substituted dibenzoxazepine compounds, pharmaceutical compositions and methods of use | SEARLE & CO (US) | 2000-07-26 | — | — | EP | disclosed |
| US-5576315-A | Substituted dibenzoxazepine compounds and methods for treating osteoporosis and ischemia | G.D. SEARLE & CO. (US) | 1996-11-19 | — | — | US | disclosed |
| EP-0694546-A2 | Substituted dibenzoxazepine compounds, pharmaceutical compositions and methods of use | G.D. SEARLE & CO. (US) | 1996-01-31 | — | — | EP | disclosed |
| EP-0694545-A2 | Substituted dibenzoxazepine compounds, pharmaceutical compositions and methods of use | G.D. SEARLE & CO. (US) | 1996-01-31 | — | — | EP | disclosed |
| US-5464830-A | ANALGESICS | G. D. SEARLE & CO. (US) | 1995-11-07 | — | — | US | disclosed |
| US-5378840-A | Substituted dibenzoxazepine compounds | G. D. SEARLE & CO. (US) | 1995-01-03 | — | — | US | disclosed |
| WO-1992019617-A2 | SUBSTITUTED DIBENZOXAZEPINE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE | G.D. SEARLE & CO. (US) | 1992-11-12 | — | — | WO | disclosed |
| EP-0512400-A1 | Substituted dibenzoxazepine compounds, pharmaceutical compositions and methods of use | G.D. Searle & Co. (US) | 1992-11-11 | — | — | EP | disclosed |