Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 2/20 | 0.84 |
| ▸ | SLCO1B1 | Q9Y6L6 | 2/20 | 0.84 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.84 |
| ▸ | ABCC2 | Q92887 | 1/20 | 0.84 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.50 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.50 |
| ▸ | RHOC | P08134 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.50 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7817499 | 1.00 | HMGCR (0.84) | HMGCRSLCO1B1ABCB1ABCC2NR1I2 | |
| Atorvastatin Lactone SCHEMBL1258955 | 0.92 | HMGCR (1.00) | HMGCRSLCO1B1ABCB1ABCC2NR1I2 | |
| Atorvastatin Lactone SCHEMBL13762456 | 0.92 | HMGCR (1.00) | HMGCRSLCO1B1ABCB1ABCC2NR1I2 | |
| Atorvastatin Lactone SCHEMBL12060138 | 0.92 | HMGCR (1.00) | HMGCRSLCO1B1ABCB1ABCC2NR1I2 | |
| Atorvastatin Lactone SCHEMBL10025147 | 0.92 | HMGCR (1.00) | HMGCRSLCO1B1ABCB1ABCC2NR1I2 | |
| Atorvastatin Lactone SCHEMBL1266 | 0.92 | HMGCR (1.00) | HMGCRSLCO1B1ABCB1ABCC2NR1I2 | |
| Atorvastatin Lactone SCHEMBL12648491 | 0.92 | HMGCR (1.00) | HMGCRSLCO1B1ABCB1ABCC2NR1I2 | |
| Atorvastatin Lactone SCHEMBL1265 | 0.92 | HMGCR (1.00) | HMGCRSLCO1B1ABCB1ABCC2NR1I2 | |
| SCHEMBL5605464 | 0.91 | HMGCR (0.93) | HMGCRSLCO1B1ABCB1ABCC2NR1I2 | |
| SCHEMBL5605468 | 0.91 | HMGCR (0.93) | HMGCRSLCO1B1ABCB1ABCC2NR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016142954-A2 | IMPROVED PROCESS FOR THE PREPARATION OF [3R,5R]-2-FLUOROPHENYL-β,δ- DIHYDROXY-5-(1-METHYLETHYL)-3-PHENYL-4-[(2-HYDROXYPHENYLAMINO)- CARBONYL]-1H-PYRROLE-1-HEPTANOIC ACID, SODIUM SALT | MSN LABORATORIES PRIVATE LIMITED (IN) | 2016-09-15 | — | — | WO | disclosed |
| EP-0680963-B1 | (Hydroxyphenylamino)carbonyl pyrroles | WARNER LAMBERT CO (US) | 2001-11-21 | — | — | EP | disclosed |
| EP-0680963-A1 | (Hydroxyphenylamino)carbonyl pyrroles | WARNER-LAMBERT COMPANY (US) | 1995-11-08 | — | — | EP | disclosed |
| US-5385929-A | Anticholesterol agents | WARNER-LAMBERT COMPANY (US) | 1995-01-31 | — | — | US | disclosed |