Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 6/20 | 0.42 |
| ▸ | TDP2 | O95551 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | ECE1 | P42892 | 1/20 | 0.38 |
| ▸ | MUS81 | Q96NY9 | 1/20 | 0.38 |
| ▸ | PRKCG | P05129 | 1/20 | 0.37 |
| ▸ | PRKCB | P05771 | 1/20 | 0.37 |
| ▸ | PRKCA | P17252 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.37 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | EHMT2 | Q96KQ7 | 5/20 | 0.36 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.36 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.36 |
| ▸ | NQO1 | P15559 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7810513 | 0.94 | TOP2A (0.43) | TOP2ATDP2TDP1ECE1MUS81 | |
| SCHEMBL7810277 | 0.94 | TOP2A (0.42) | TOP2ATDP2TDP1ECE1MUS81 | |
| SCHEMBL7817250 | 0.93 | TOP2A (0.44) | TOP2ATDP2TDP1ECE1MUS81 | |
| SCHEMBL7810327 | 0.92 | ECE1 (0.43) | TOP2ATDP2TDP1ECE1MUS81 | |
| SCHEMBL7818986 | 0.92 | TOP2A (0.47) | TOP2AECE1MUS81EHMT2MALT1 | |
| SCHEMBL7804758 | 0.90 | TOP2A (0.43) | TOP2ATDP2TDP1ECE1MUS81 | |
| SCHEMBL7805085 | 0.89 | ECE1 (0.40) | TOP2ATDP2TDP1ECE1MUS81 | |
| Topixantrone SCHEMBL29371930 | 0.88 | TOP2A (0.57) | TOP2ATDP1ECE1MUS81KCNH2 | |
| Topixantrone SCHEMBL1344518 | 0.88 | TOP2A (0.57) | TOP2ATDP1ECE1MUS81KCNH2 | |
| SCHEMBL7810464 | 0.88 | TOP2A (0.42) | TOP2ATDP2TDP1ECE1MUS81 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0750619-B1 | HETERO-ANNULATED INDAZOLES | NOVUSPHARMA SPA (IT) | 2001-05-30 | — | — | EP | claimed |
| EP-0750619-A1 | HETERO-ANNULATED INDAZOLES | BOEHRINGER MANNHEIM ITALIA S.p.A. (IT) | 1997-01-02 | — | — | EP | claimed |
| WO-1995024407-A1 | HETERO-ANNULATED INDAZOLES | BOEHRINGER MANNHEIM ITALIA, S.P.A. (IT) | 1995-09-14 | — | — | WO | claimed |
| EP-0750619-B1 | HETERO-ANNULATED INDAZOLES | NOVUSPHARMA SPA (IT) | 2001-05-30 | — | — | EP | disclosed |
| US-5596097-A | ANTITUMOR AGENTS | THE UNIVERSITY OF VERMONT (US) | 1997-01-21 | — | — | US | disclosed |
| EP-0750619-A1 | HETERO-ANNULATED INDAZOLES | BOEHRINGER MANNHEIM ITALIA S.p.A. (IT) | 1997-01-02 | — | — | EP | disclosed |
| WO-1995024407-A1 | HETERO-ANNULATED INDAZOLES | BOEHRINGER MANNHEIM ITALIA, S.P.A. (IT) | 1995-09-14 | — | — | WO | disclosed |