Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.38 |
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.37 |
| ▸ | NPC1 | O15118 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | GAA | P10253 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | HPGD | P15428 | 3/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.33 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.33 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7814935 | 0.86 | NPC1 (0.36) | MAP3K14SMN1; SMN2NPC1RAB9ATRPA1 | |
| SCHEMBL2157981 | 0.76 | CYP11B1 (0.39) | ALDH1A1KDM4EKMT2AMEN1 | |
| SCHEMBL4894034 | 0.76 | TLR8 (0.37) | NPC1RAB9AALDH1A1KDM4EGAA | |
| SCHEMBL7814303 | 0.75 | MAPT (0.48) | ACSS2SMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL5982654 | 0.74 | PTPN1 (0.42) | SMN1; SMN2NPC1RAB9AALDH1A1KDM4E | |
| SCHEMBL7814408 | 0.74 | NPM1 (0.35) | SMN1; SMN2NPC1RAB9AALDH1A1HTT | |
| SCHEMBL7815237 | 0.74 | ESR1 (0.37) | ALDH1A1KDM4EHPGDHTTHSD17B10 | |
| SCHEMBL3649032 | 0.72 | CA12 (0.48) | SMN1; SMN2NPC1RAB9AALDH1A1KDM4E | |
| SCHEMBL7811025 | 0.71 | SCN10A (0.35) | SMN1; SMN2NPC1RAB9AALDH1A1GAA | |
| SCHEMBL7814533 | 0.70 | GPBAR1 (0.36) | SMN1; SMN2GAAHSD17B10MAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0745600-B1 | Benzimidazole derivatives, their preparation and their therapeutic use | SANKYO CO (JP) | 2001-10-24 | — | — | EP | disclosed |
| US-5886014-A | TREATMENT AND/OR PROPHYLAXIS OF A VARIETY OF DISORDERS, INCLUDING HYPERLIPEMIA, HYPERGLYCEMIA, OBESITY, IMPAIRED GLUCOSE TOLERANCE (IGT), INSULIN RESISTANCE AND DIABETIC COMPLICATIONS | SANKYO COMPANY, LIMITED (JP) | 1999-03-23 | — | — | US | disclosed |
| EP-0745600-A1 | Benzimidazole derivatives, their preparation and their therapeutic use | SANKYO COMPANY LIMITED (JP) | 1996-12-04 | — | — | EP | disclosed |