Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 16/20 | 0.57 |
| ▸ | DRD2 | P14416 | 15/20 | 0.57 |
| ▸ | HTR1A | P08908 | 1/20 | 0.55 |
| ▸ | HTR2A | P28223 | 1/20 | 0.55 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.42 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8588828 | 1.00 | DRD4 (0.57) | DRD4DRD2HTR1AHTR2AADORA2A | |
| SCHEMBL5410903 | 0.93 | DRD4 (0.67) | DRD4DRD2HTR1AHTR2AADORA2A | |
| SCHEMBL7824302 | 0.84 | DRD4 (0.59) | DRD4DRD2HTR1AHTR2AADORA2A | |
| SCHEMBL7832682 | 0.83 | DRD4 (0.57) | DRD4DRD2HTR1AHTR2AADORA2A | |
| SCHEMBL7832677 | 0.83 | DRD4 (0.57) | DRD4DRD2HTR1AHTR2AADORA2A | |
| SCHEMBL6907064 | 0.83 | DRD4 (0.60) | DRD4DRD2HTR1AHTR2AADORA2A | |
| SCHEMBL7994734 | 0.83 | DRD4 (0.60) | DRD4DRD2HTR1AHTR2AADORA2A | |
| SCHEMBL7820625 | 0.82 | DRD4 (0.69) | DRD4DRD2HTR1AHTR2A | |
| SCHEMBL7820261 | 0.82 | DRD4 (0.58) | DRD4DRD2HTR1AHTR2AADORA2A | |
| SCHEMBL7823455 | 0.80 | DRD4 (0.55) | DRD4DRD2HTR1AHTR2AADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0874849-B1 | 2,7-SUBSTITUTED OCTAHYDRO-PYRROLO 1,2-A]PYRAZINE DERIVATIVES | PFIZER (US) | 2001-09-19 | — | — | EP | disclosed |
| US-6284757-B1 | ANTISEROTINONE AGENT | PFIZER INC. | 2001-09-04 | — | — | US | disclosed |
| EP-0982030-A2 | 2,7-substituted octahydro-pyrrolo 1,2-a]pyrazine derivatives as 5ht 1a ligands | Pfizer Products Inc. (US) | 2000-03-01 | — | — | EP | disclosed |
| EP-0874849-A1 | 2,7-SUBSTITUTED OCTAHYDRO-PYRROLO 1,2-A]PYRAZINE DERIVATIVES | PFIZER INC. (US) | 1998-11-04 | — | — | EP | disclosed |
| US-5714487-A | 2,7-substituted octahydro-pyrrolo 1,2-a!pyrazine derivatives | PFIZER INC. (US) | 1998-02-03 | — | — | US | disclosed |
| WO-1997023482-A1 | 2,7-SUBSTITUTED OCTAHYDRO-PYRROLO[1,2-A]PYRAZINE DERIVATIVES | PFIZER INC. (US) | 1997-07-03 | — | — | WO | disclosed |