Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 20/20 | 1.00 |
| ▸ | PDE4B | Q07343 | 20/20 | 1.00 |
| ▸ | PDE4C | Q08493 | 20/20 | 1.00 |
| ▸ | PDE4D | Q08499 | 20/20 | 1.00 |
| ▸ | PDE3B | Q13370 | 17/20 | 1.00 |
| ▸ | PDE3A | Q14432 | 17/20 | 1.00 |
| ▸ | PDE5A | O76074 | 11/20 | 1.00 |
| ▸ | PDE1A | P54750 | 11/20 | 1.00 |
| ▸ | PDE1B | Q01064 | 11/20 | 1.00 |
| ▸ | PDE1C | Q14123 | 11/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7819570 | 1.00 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7821690 | 0.94 | PDE4A (0.89) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7821142 | 0.91 | PDE4A (0.84) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7156582 | 0.88 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7156583 | 0.88 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7818726 | 0.88 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7819538 | 0.87 | PDE4A (0.84) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7819349 | 0.86 | PDE4A (0.76) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7164328 | 0.86 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7164331 | 0.86 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DPDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0828742-B1 | DIAZEPINO-INDOLES AS PHOSPHODIESTERASE IV INHIBITORS | JOUVEINAL INST RECH (FR) | 2001-12-19 | — | — | EP | disclosed |
| EP-1132390-A2 | Diazepinoindoles as phophodiesterase inhibitors | INSTITUT DE RECHERCHE JOUVEINAL (FR) | 2001-09-12 | — | — | EP | disclosed |
| US-5972927-A | ANTIINFLAMMATORY, ANTIALLERGIC AND BRONCHODILATORY MEDICINAL PRODUCTS, TREATMENT OF ASTHMA | JOUVEINAL (FR) | 1999-10-26 | — | — | US | disclosed |